In this paper, the monofractal and multifractal properties of inter-beat (R-R) intervals in cardiac signals for normal and pathology classes were studied and applied to a dataset in PhysioNet which consists of 24-hour RR intervals from 54 healthy subjects (hs) and 92 patients with various diagnoses (44 with congestive heart failure (chf), 25 with atrial fibrillation (af) and 23 diagnosed with sudden death syndrome (sd)). The results in this study indicate that the most suitable method for estimating the monofractal properties of R-R intervals is detrending moving average (DMA). The Hurst exponents (H) of the healthy and pathological groups, calculated using the DMA method, are shown to be statistically different by the Kruskal-Wallis test (p-value<0.01; healthy = 0.23(0.18-0.27); pathological group = 0.
We suggest an algorithm for the estimation of the Hurst exponent that is based on the results of the well-known stabilogram diffusion analysis method of Hurst exponent estimation for one-dimensional fractals. Our algorithm can be applied to Hurst exponent estimation for fractals with two or more dimensions. To assess the efficiency of this algorithm, we compare its calculation results to those of the well-known Hurst exponent estimation detrending moving average analysis algorithm. In this paper, the computation of the Hurst exponent has been performed for two-dimensional domains of various sizes, which were generated by the Cholesky-Levinson factorization algorithm. The surrogate surfaces have Hurst exponents of H = 0.1, 0.5, and 0.9. It has been established that the detrending moving average analysis algorithm is more sensitive to high-frequency components, while the stabilogram diffusion analysis tends to be sensitive to low-frequency components.
At the present time, the therapy of most diseases requires special attention not only from the treating physician, but also from the patient. In turn, in the treatment of children, the monitoring of compliance with the treatment is carried out not by the patient, but by his parents who control the regimen of taking medications. The aim of the study was to determine the efficiency of traditional anti-H. pylori regimen in the treatment of chronic gastroduodenal pathology in children with various level of parental compliance. 80 children of school age suffering from peptic ulcer disease duodenal ulcer associated with H. pylori from families with different levels of parental compliance were examined. The traditional anti-H. pylori therapy scheme containing omeprazole, clarithromycin lasting 14 days was prescribed for all children with chronic gastroduodenal pathology. It is established that strict adherence to the regimen and duration of administration of prescribed drugs allows achieving a high level of eradication of H. pylori even with the use of the traditional anti-Helicobacter pylori. Conducting a “compliance training” before starting therapy is an important factor that increases the level of parental compliance in patients with inflammatory-destructive diseases of the stomach and duodenum. Establishment of interpersonal relationships in the “doctor-patient-parent” system, working with parents, aimed at explaining the essence of the disease, the consequences of the disease, treatment tactics are an important stage in the therapy of a sick child.
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