ABSTRACT.Objective: To evaluate three different techniques to quantify retinal blood flow transit times in normal human eyes from fluorescein angiograms. Subjects and Methods: Fluorescein angiograms were recorded on two different occasions in 18 normal individuals with a scanning laser ophthalmoscope. The angiograms were digitized (5 frames per second) and the images were aligned.
Mean transit times (MTT) were analysed with a newly developed technique based on an impulse-response analysis (MTT IR ) and again with the conventional technique (MTT SLOPE)
Conclusions:Mean transit time is a well-defined physiological parameter. The technique based on impulse-response analysis allows for analysis of even badly defined dye curves. We found this technique to be superior to the conventional technique in terms of reproducibility.
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