Olive (Olea europaea) have been cultivated and grown well in tropical climates such as Indonesia. Indonesia local community have used olive as herbal medicines due to its active compounds known as oleuropein that has many biological activities including as neurotherapy in Alzheimer's disease. The purpose of this study is to explore the potential phenolic compounds of olive and examine the acetylcholinesterase (AChE) inhibitory activity displayed by different olive polyphenols through a silico approach. The bioactive compounds of olive which had been analyzed in this study were phenolic compound included oleuropein, demethyl-oleuropein, ligstroside, oleoside, verbascoside, luteolin 7-glucoside, and hydroxytyrosol. Interaction of bioactive compounds with acetylcholinesterase (AChE) was analyzed through molecular specific docking using AutoDock Vina with Pyrx Software. The result elucidate that olive contain potential biological activities as antioxidant, anti-inflammatory, antineoplastic, free radical scavenger, antibacterial, antifungal, expression TP53 enhancer, caspase 8 stimulant, platelet adhesion inhibitor, treatment for lipoprotein disorder, antiviral and dementia treatment/Alzheimer disease. The highest bioactivity percentage of olive phenolic compound are as an antioxidant of 82%, anti-inflammatory of 73%, and anti-cancer (antineoplastic) of 70% respectively. Based on molecular docking analysis show one of olive phenolic compound of the dimethyl-oleuropein has strong interaction with AChE as pointed in the binding affinity of demethyl-oleuropein +AChE of-8.9 kcal/mol has closed to galanthamine binding affinity of-10.3 kcal/mol. Along with glutamate acid 202, tyrosine 133 and tyrosine 124 are the major contributors in the target-ligand interactions. The selected demethyl-oleuropein ought to be tested in clinical studies to discover new neuro-therapeutic candidates.
2 Program Studi Kedokteran, Fakultas Kedokteran, Universitas Islam Malang, Malang *Korespondensi dengan penulis (oktaviarahayu89@gmail.com) Artikel ini dikirim pada tanggal 11 Desember 2017 dan dinyatakan diterima tanggal 28 Februari 2018. Artikel ini juga dipublikasi secara online melalui www.jatp.ift.or.id. Hak cipta dilindungi undang-undang. Dilarang diperbanyak untuk tujuan komersial. Diproduksi oleh Indonesian Food Technologists® ©2018 AbstrakPenelitian bertujuan untuk mengetahui pengaruh lama simpan refrigerator terhadap kadar protein, kadar lemak dan solid non fat (SNF) susu kambing pasteurisasi. Penelitian ini telah dilaksanakan di Laboratorium Teknologi Hasil ternak, Fakultas Peternakan, Universitas Islam Malang mulai tanggal 01 Juli -21 Agustus 2017. Materi yang digunakan adalah susu kambing, gula, alat pasteurisasi sederhana, refrigerator, lactoscan. Metode dalam penelitian ini adalah eksperimen. Parameter yang diamati adalah kadar protein, kadar lemak dan solid non fat (SNF). Pengujian kadar protein, kadar lemak, dan SNF menggunakan alat lactoscan. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan 5 perlakuan lama simpan yaitu P1 (1 hari), P2 (3 hari), P3 (6 hari), P4 (9 hari), P5 (12 hari) penyimpanan dan 4 ulangan. Data yang diperoleh dianalisis dengan analisis of variance (ANOVA) dan dilanjut dengan uji duncan apabila terdapat pengaruh. Hasil penelitian menunjukkan adanya lama penyimpanan refrigerator mempengaruhi kadar protein, kadar lemak, dan SNF susu kambing pasteurisasi (P<0,05). Kadar protein, lemak dan SNF tertinggi pada penyimpanan P1 sebesar 4,26±0,01, 6,93±0,01, 8,30±0,01. Penyimpanan susu kambing pasteurisasi pada refrigerator selama 9 hari pada refrigerator menghasilkan kadar protein, kadar lemak dan SNF sesuai standar SNI. Kesimpulannya adalah penyimpanan susu kambing pasteurisasi pada refrigerator selama 9 hari masih dapat dikatakan aman untuk dikonsumsi.Kata kunci: susu kambing pasteurisasi, penyimpanan refrigerator, protein, lemak, solid non fat AbstractThe aim of this research is to know the influence of refrigerator saving to protein content, fat content and solid non fat (SNF) of pasteurized goat milk. This research was conducted in Animal Production Technology Laboratory, Faculty of Animal Husbandry, Islamic University of Malang from July 01-August 21 st , 2017. Goat milk, sugar, simple pasteurization, refrigerator, lactoscan were used in this research. The obtained fresh goat milk was pasteurized at 71.2°C for 15 seconds. The storage of pasteurized goat milk was done in the refrigerator for 12 days. During storage, protein content, fat content and SNF were observed. Testing protein levels, fat content, and SNF using lactoscan. The experimental design used a complete randomized design with 5 treatments, i.e. P1 (1 day), P2 (3 days), P3 (6 days), P4 (9 days), P5 (12 days) of storage. The data were analyzed by analysis of variance (ANOVA) and continued with Duncan test if there was significant effect. The results showed that refrigerator storage significantly...
Limbah usaha peternakan dapat menimbulkan permasalahan lingkungan sekitar pemukiman dimana usaha peternakan berada, jika tidak dikelola dengan baik. Oleh karena itu muncullah inovasi baru, diantaranya pemanfaatan produk limbah kotoran agar menjadi produk yang memiliki nilai jual dan diharapkan mampu menjaga ketahanan ekonomi masyarakat sekitar dan limbah kotoran juga diharapkan mampu mengurangi pencemaran lingkungan yang terjadi. Tujuan pengabdian ini adalah memberdayakan masyarakat desa Kidal Kecamatan Tumpang, Desa Banjararum Kecamatan Singosari Kabupaten Malang melalui teknologi pengolahan pengolahan pupuk organik. Kegiatan ini menggunakan metode pendekatan yaitu tahap pertama observasi kondisi awal potensi peternakan yang dihadapi oleh masyarakat mengenai limbah. Tahap kedua adalah perencanaan untuk memecahkan masalah berupa kegiatan sosialisasi dan pelatihan pembuatan produk secara langsung. Tahap ketiga adalah sosialisasi dan pelatihan pembuatan pupuk organik. Tahap terakhir evaluasi program. Hasil kegiatan sosialisasi dan pelatihan pembuatan produk adalah meningkatkan pengetahuan kepada para peternak bahwa limbah dapat dimanfaatkan sebagai pupuk organik kompos sehingga timbulnya kesadaran petani dan peternak untuk memulai dan mengembangkan kebiasaan memberikan pupuk kompos organik yang baik bagi tanaman serta peternak dapat membuat pupuk organik secara mandiri dengan menggunakan bantuan bakteri em-4 yang berfungsi sebagai aktivator kompos melalui proses fermentasi. Kesimpulannya adalah masyarakat desa memahami adanya potensi olahan limbah menjadi produk pupuk organik. Dengan adanya inovasi tersebut membantu perekonomian masyarakat dan mengurangi dampak limbah peternakan serta mengurangi ketergantungan penggunaan pupuk kimia di Desa Kidal Kecamatan Tumpang, Desa Banjararum Kecamatan Singosari Kabupaten Malang.
Malang is a rich culinary city of livestock products such as pasteurized milk. The purposes of this study were analyzed total microbes, contamination of Escherichia coli and pH of pasteurized milk produced by milk store, village unit cooperation milk house and STMJ cafe in Malang. The method of this research were survey and experiment. The samples were took from milk store (P1), village unit cooperation milk house (P2) and STMJ café (P3) in Malang during 4 days. The data analysis of total microbial and pH using one-way analysis of variance (ANOVA) and continued by Duncan Multiple Range Test (DMRT) while Escherichia coli data was analyzed by descriptive analysis. The results showed that there were a real influence (P<0,05) of milk producers on total microbes and pH. Escherichia coli contaminant from three producers were showed the same results which were less than 3 apm/ml. The conclusions of this study were total microbes and contamination of Escherichia coli original pasteurized milk produced by milk store, village unit cooperation milk house and STMJ cafe under the limit of microbial contamination on food. Microbiological quality in terms of total microbes, and contamination of Escherichia coli pasteurized milk by milk store in Malang City were classified to national standard of pasteurized milk in Indonesia. Keywords: Total Microbes, Escherichia coli, pH, Pasteurized Milk, Malang City
The COVID-19 pandemic has had a social impact on the world community and Indonesia in particular, causing social inequality in people's lives. Therefore, the role of youth fighters is needed for the welfare of the community. The problem raised in this study is how to form a synergy of young fighters in the welfare of society. The purpose of this study is to analyze the form of synergy of progressive young fighters with the welfare of the community in the era of the covid-19 pandemic. The method used is qualitative. The results of this study obtained a form of synergy of young fighters in community welfare in the form of verifying and validating integrated social welfare data then conducting social mapping, and also conducting social-preneur activities.
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