The publication analyzes the experience of implementing the practices of participatory budgeting in the regions of the Siberian Federal District in the framework of the directions of the project of the Ministry of Finance of the Russian Federation "Budget for citizens". the implementation of the practice of participatory budgeting from 2019 to 2022 in the Krasnoyarsk Territory, the Altai Territory, the Irkutsk Region, the Novosibirsk Region, the Altai Republic, the Tomsk Region, the Kemerovo Region, the Republic of Tyva, the Omsk Region is considered.
The materials of the article reveal the importance of implementing the principle of openness of state (federal, sub-federal) and municipal budgets in ensuring effective budgetary policy of the state. Methodological approaches to assessing the openness of budgets in international and Russian practice are considered. the ratings of the subjects of the Russian Federation (subjects of the Siberian Federal District) on the level of openness of budget data for 2021 in comparison with 2020 are given. the model of budget openness formed in the Russian Federation and the main directions of its further development are presented.
Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Materials and methods: Experimental studies were conducted on white nonlinear rats. To induce experimental allergic encephalomyelitis (EAE), homologous brain homogenates was used, which leads among other drugs (homologous, heterogeneous brain and spinal cord homogenates) by encephalitogenity. The connective tissue of the animal’s tail base was injected with a mixture of encephalitogenic suspension of 0.1 ml per 100 g of the body weight.
Results and discussion: According to the results, in the rats, there was weight loss, and the abnormal neurological symptoms were found on an average of 10–12th days. Our experimental studies on the formation of EAE were confirmed morphologically by electron microscopy.
Conclusion: Thus, the use of this technique allowed us to obtain a simulated pathologic condition of multiple sclerosis in the form of experimental allergic encephalomyelitis and can be used in future studies to identify appropriate laws, the extent and nature of changes in the immune and nervous systems of the body when inducing experimental pathological conditions.
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