Extension of the dynamic range of liquid crystal tunable Lyot filter is demonstrated by incorporating with it a liquid crystal variable retarder as an eliminator for the third and fourth order peaks. The filter is continuously tunable in the range 500 nm to 900 nm with a nominal width in the range 50nm-100nm. Design procedure is described including the exact solution to the LC director profile and the suitability for biomedical optical imaging applications. Flexibility in the design is proposed by applying different voltages to the different liquid crystal retarders thus compensating for small thickness deviations from the nominal values and obtaining the high dynamic range.

Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by spectral and polarization changes of light backscattered by the examined tissue. A new differential spectropolarimetric system is proposed using liquid crystal devices, one as a tunable filter and the other as a polarization rotator, both operating at wide spectral ranges from the visible to the near-infrared. Since collagen's fibrils texture orientation depends on its location in the skin and since it is not well organized, our system scans the bipolarization states by continuously rotating the linearly polarized light incident on a skin lesion, and collecting differential contrasts between sequenced images when simultaneously averaging the statistical readout of a video camera. This noninvasive method emphasizes areas on skin where the neoplasm, or tumor, minimizes the statistical polarization change of the scattered light from the lesion. The module can be considered as an assistant tool for epiluminescence microscopy. Images of skin tumors were captured in vivo before the patients having their surgery and compared to histopathological results.

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Spectropolarimetric skin imaging is becoming an attractive technique for early detection of skin cancer. Using two liquid crystal retarders in combination with a dual-band passive spectral filter and two linear polarizers, we demonstrate the spectral and polarimetric imaging of skin tissue in the near infrared. Based on this concept, a compact prototype module has been built and is being used for clinical evaluation.

A novel (to our knowledge) concept for a tunable birefringent filter with a high dynamic range is proposed and demonstrated by using a stack of liquid-crystal retarders having different thicknesses following an arithmetic sequence. Each retarder is between crossed polarizers with its optic axis oriented azimuthally at 45 degrees to the polarizer axis. The tunable filter was fabricated by using nematic liquid crystals demonstrating tunability over a range of 800 nm, covering the visible and the near IR; hence it has a potential for use in biomedical optical imaging applications.