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The lethal toxicity and lipid peroxidation studies of Alstonia boonei on alloxan induced diabetic rats were analysed. The effect of ethanol leaf extract of A. boonei on the kidney markers of diabetic rat was also determined. The acute toxicity of the ethanol extract of A. boonei was found to be more than 5000 mg/kg body weight of the extract after 24 h of constant observation. The malondialdehyde concentration of the rats treated with 200 and 400 mg/kg body weights of the extract significantly decreased (p<0.05) when compared with the untreated diabetic rats. There was no significant difference (p>0.05) when malondialdehyde concentrations of rat treated with 200 and 400 mg/kg body weights of the extracts were compared with the standard control. But the creatinine concentration decreased significantly (p<0.05) when 200 and 400 mg/kg body weights of the extract of the treated diabetic animals were compared with the diabetic control.

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The effects of the ethanol extract from Buchholzia coriacea seed on inflammatory response using fresh egg albumin-induced paw edema in rats were examined. Antinociceptive activity of the extract using writhing test with acetic acid-induced pain in mice and the antipyretic activity in yeast-induced fever in rats were also examined. Oral administration of the extract (at the dose of 400mg/kg and in a dose dependent manner) significantly (p< 0.05) decreased the paw oedema induced by fresh egg albumin in rats. The extract (at 400mg/kg) also significantly (p< 0.05) inhibited yeast-induced pyrexia in rats when compared to the control. The extract was also found to possess significant (p< 0.05) dose dependent antinociceptive response in mice at 800 mg /kg. The results support the use of Buchholzia extract for the treatment of inflammatory disorders.