Acute toxicity, lipid peroxidation and ameliorative properties of Alstonia boonei ethanol leaf extract on the kidney markers of alloxan induced diabetic rats

Abstract

The lethal toxicity and lipid peroxidation studies of Alstonia boonei on alloxan induced diabetic rats were analysed. The effect of ethanol leaf extract of A. boonei on the kidney markers of diabetic rat was also determined. The acute toxicity of the ethanol extract of A. boonei was found to be more than 5000 mg/kg body weight of the extract after 24 h of constant observation. The malondialdehyde concentration of the rats treated with 200 and 400 mg/kg body weights of the extract significantly decreased (p<0.05) when compared with the untreated diabetic rats. There was no significant difference (p>0.05) when malondialdehyde concentrations of rat treated with 200 and 400 mg/kg body weights of the extracts were compared with the standard control. But the creatinine concentration decreased significantly (p<0.05) when 200 and 400 mg/kg body weights of the extract of the treated diabetic animals were compared with the diabetic control.

Evaluation of Antimalarial Potential of Extracts from Alstonia boonei and Carica papaya in Plasmodium berghei-Infected Mice

“…This shows that the extract may be safe for in vivo administration up to 2000 mg/kg. Our result of acute toxicity test is similar to the results of the study by Enechi et al, which showed that Alstonia boonei was tolerated up to a dose of 5000 mg/kg [ 33 ]. Similarly, Solikhah et al reported zero death for mice administered the leaf extract of Carica papaya up to a dose of 3000 mg/kg [ 34 ].…”

Comparative studies of genotoxicity and anti-plasmodial activities of stem and leaf extracts of <i>Alstonia boonei</i> (De Wild) in malaria-infected mice

“…Therefore, the need for continuous scientific search for new drugs with novel modes of action in parasite clearance, restoration of damaged organs/cells during malaria pathogenesis and less toxicity is exigent [6]. In Africa, A. boonei is one of the widely used plants in the treatment of fever-related diseases [7]. The plant belongs to the family Apocynaceae found in the continents of Africa, Asia and America [8].…”

Prevalence and Associated Factors of Urinary Tract Infections among Diabetic Patients: A Study at Kiryandongo Hospital, Uganda

“…It is generally acknowledged that women are more likely than men to have UTIs due to their reproductive function [26][27][28][29][30]. This is supported by another study in Ethiopia, which showed that female patients with diabetes were 3.77 times more likely to develop UTI than their counterparts [30][31][32][33][34]. This also appears to be connected to proximity to the anus, physiological bladder alterations brought on by aging or shortness of breath, and bladder neurological dysfunction [27][28][29][30][31][32]).…”

“…This could be due to the long-term effects of diabetes, such as neuropathy and an impaired immune system. Chronic hyperglycemia may cause renal papillary necrosis, nephropathy, and cystopathy, which increase the risk of UTI [29][30][31][32][33][34].…”