The visual evoked potentials technique records the cerebral bioelectric activity generated by light stimulation. Evoked potentials is a good method of assessing the electrical response of the brain to different stimuli and has been used extensively in the study of brain disturbances. We registered VEP on 18 hyperthyroid and 18 hypothyroid patients, without other endocrine, metabolic, ophthalmologic or neurological illnesses, the 2 groups having practically identical ages, but sex repartition, illness age and treatment duration being statistically different (p[0.001). Hormonal, radiological, biochemical dosages and physiological paraclinic determinations were performed on all 36 subjects, through classical methods, and VEP recordings, with a 4 channel polygraph through pattern reversal stimulation (1 Hz), measuring all parameters (latency, amplitude, duration, surface, steepness etc.) of N75 and P100 waves. Between groups, the recorded hormone levels and other recordings showed great differences, very highly statistically significant (p[0.001), only arterial pressures being just statistically significant (p[0.05). The Pearson�s r correlation coefficients indicated extremely high correlations (r=0.90-0.98) between all parameters. Between the 2 groups, hypothyroid patients had latencies of P100 wave higher with 17.88% (p=0.0028) and of the N75 wave with 9.98% (p=0.016), and the duration of the N75 wave lower with 26.37% (p=0.026), the other parameters of VEP waves modifying up to 52.35%, not statistically sgnificant due to high standard deviations. The duration of N75 correlates with the majority of humoral-paraclinical parameters, indicating a functional interdependency between them and the function of the cortex. The ratio of the amplitudes and of the areas of P100/N75 indicate a severe inhibition to hypothyroid patients, a precisely quantified reduction of the cerebral activity.

The aim of the study was to assess the correlations between the acute confusing syndrome and different comorbidities found in a group of 126 elderly patients with this diagnosis, who were admitted to the Neurology Clinic of the Neuropsychiatry Hospital of Craiova. The main syndromes highlighted at the neurological examination were confusing, pyramidal and vestibular syndromes. The acute confusing syndrome has a multifactorial etiology, due to the wide range of comorbidities encountered in elderly patients. In our study the most frequent comorbidities were cardiovascular pathology, diabetes mellitus, dyslipidemia, cerebrovascular renal, hepatic pathology.

Anemia associated with ribavirin (RBV) and interferon therapy in patients with chronic viral hepatitis C is a hemolytic, multifactorial adverse effect, in direct correlation with the RBV dose. Additionally, the anemic syndrome is worsened by the interferon-induced bone marrow suppression of erythroid precursors. The resulting anemia is associated with low production of erythropoietin, similar to anemia seen in HIV-infected patients or in those with cancer. Our study was performed on a group of 28 patients with viral hepatitis C treated with 3 MU interferon alfa 3 times a week and RBV 1000-1200 mg/day for 12 months. A normochromic normocytic anemia was observed, requiring a reduction of the RBV dose to 600 mg/day if the hemoglobin was below 10 g/dL and interrupted if the hemoglobin level was below 8.5 g/dL. In this case, reversibility can occur within a time interval of 4-8 weeks after discontinuation of treatment.

Pancreatic adenocarcinomas are considered one of the most complicated cancers in terms of treatment options and patient management. Regarding the diagnosis of pancreatic cancers, imaging techniques still play the central role with multiple options such as Computer Tomography (CT), Ultrasound (US), or Endoscopic Ultrasound (EUS) being available. The study was conducted at the Emergency County Hospital of Craiova, at the Radiology and Medical Imaging Department, the Imaging Compartment of the Research Center of Gastroenterology and Hepatology Research Center, on 170 patients suffering from pancreatic cancer, mostly adenocarcinomas. The neoplastic lesions were described using either US, CT or EUS techniques. The location of the tumor was assessed suing US and CT examination for all 170 patients in the study. There was a statistically significant correlation ([ 0.0001) between US and CT examination in terms of accuracy, with both techniques proving to be highly reliable. For measuring tumor size, 31 patients were evaluated using CT and EUS techniques. EUS proved to be more accurate in comparison to CT examination, with 9 (27%) of the total 31 patients having their tumor size underestimated by CT examination. There are no notable differences between the US evaluation of the tumor location and the actual location identified at the CT scan. As for tumor size, EUS showed greater reliability in evaluating tumor size in comparison to CT examination.