The Relationship between the Acute Confusing State and the Comorbidities of the Elderly Patient

Albu, Valeria Carmen; Sandu, Raluca Elena; Bărbulescu, Andreea Lili; Tartea, Elena-Anca; Burada, Emilia; Taisescu, Oana; Vreju, F.; Boldeanu, Mihail Virgil; Boldeanu, Lidia; Enescu, A; Pascoveanu, Denisa; Stoian, Andreea Cristina; Catalin, Bogdan; Musatescu, Anca Emanuela

doi:10.37358/rc.19.7.7352

Cited by 4 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These concurrent medical conditions, often present in individuals afflicted by stroke, contribute significantly to the complexity of the condition [172]. On the other hand, individuals maintaining a healthy lifestyle, characterized by abstaining from smoking, engaging in daily exercise, moderate alcohol consumption, and maintaining a moderate weight in their mid-forties, experienced a notably reduced risk of developing stroke [173] and neurodegenerative diseases compared to those with high-risk lifestyles [174,175]. In stroke research, prioritizing the inclusion of aged and comorbid animal models is paramount [176].…”

Section: Discussionmentioning

confidence: 99%

Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives

Pinoșanu,

Pîrșcoveanu,

Albu

et al. 2024

CIMB

Self Cite

View full text Add to dashboard Cite

Ischemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR signaling regulates cell growth, proliferation, and autophagy. Preclinical studies have demonstrated the neuroprotective effects of targeting these pathways in stroke models, offering insights into potential treatment strategies. However, challenges such as off-target effects and the need for tissue-specific targeting remain. Furthermore, emerging evidence suggests the therapeutic potential of MSC secretome in stroke treatment, highlighting the importance of exploring alternative approaches. Future research directions include elucidating the precise mechanisms of action, optimizing treatment protocols, and translating preclinical findings into clinical practice for improved stroke outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives

Pinoșanu,

Pîrșcoveanu,

Albu

et al. 2024

CIMB

Self Cite

View full text Add to dashboard Cite

show abstract

“…In terms of oxidative stress, we observed a marked increase in lipid peroxidation, as indicated by elevated TBARS levels in patients with both ischemic stroke and COVID-19, compared to the control group. This suggests a potentiation effect, where the co-occurrence of these conditions leads to exacerbated oxidative damage [32][33][34][35][36][37][38]. While protein oxidation (PCARB) displayed a subtle elevation, the absence of statistical significance implies that lipid peroxidation plays a more substantial role in this combined pathology.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Antioxidant Defense Mechanisms in Acute Ischemic Stroke Patients with Concurrent COVID-19 Infection

Pinoșanu,

Surugiu,

Burada

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Stroke remains a debilitating cerebrovascular condition associated with oxidative stress, while COVID-19 has emerged as a global health crisis with multifaceted systemic implications. This study investigates the hypothesis that patients experiencing acute ischemic stroke alongside COVID-19 exhibit elevated oxidative stress markers and altered antioxidant defense mechanisms compared to those with acute ischemic stroke. We conducted a single-center prospective cross-sectional study to investigate oxidative stress balance through oxidative damage markers: TBARS (thiobarbituric acid reactive substances level) and PCARB (protein carbonyls); antioxidant defense mechanisms: TAC (total antioxidant capacity), GPx (glutathione peroxidase), GSH (reduced glutathione), CAT (catalase), and SOD (superoxide dismutase); as well as inflammatory response markers: NLR (neutrophil-to-lymphocyte ratio), CRP (C-reactive protein), and ESR (erythrocyte sedimentation rate). Statistical analyses and correlation models were employed to elucidate potential associations and predictive factors. Our results revealed increased oxidative stress, predominantly indicated by elevated levels of TBARS in individuals experiencing ischemic stroke alongside a concurrent COVID-19 infection (p < 0.0001). The Stroke-COVID group displayed notably elevated levels of GSH (p = 0.0139 *), GPx (p < 0.0001 ****), SOD (p = 0.0363 *), and CAT (p = 0.0237 *) activities. Multivariate analysis found a significant association for TBARS (p < 0.0001 ****), PCARB (p = 0.0259 *), and GPx activity (p < 0.0001 ****), together with NLR (p = 0.0220 *) and CRP (p = 0.0008 ***). Notably, the interplay between stroke and COVID-19 infection appears to amplify oxidative damage, potentially contributing to exacerbated neurological deficits and poorer outcomes. This study highlights the intricate relationship between oxidative stress, inflammation, and concurrent health conditions. Understanding these interactions may open avenues for novel therapeutic strategies aimed at ameliorating oxidative damage in patients with acute ischemic stroke and COVID-19, ultimately improving their prognosis and quality of life.

show abstract

“…SASD bursitis was noted, when the distension of the bursa was bigger than 2 mm . (11,15) Statistical analysis was performed using GraphPad Prism 5.5. Results are presented as mean ±SD and data were analyzed using ttest and One-way ANOVA for comparing groups, and Pearson/Spearman's coefficient for evaluating correlations.…”

Section: Ultrasonographymentioning

confidence: 99%

Shoulder Involvement in Daily Practice – Ultrasonographic Approach

et al. 2021

Self Cite

View full text Add to dashboard Cite

Shoulder involvement is one of the most frequent findings in rheumatology and many of the rheumatic diseases can determine inflammatory lesions, as well as degenerative ones. Due to the non-specificity of clinical symptoms, imaging methods are emerging into the daily practice in order to establish an accurate diagnosis. Objectives. The aim of the study was to determine the presence of different pathologic changes in patients with shoulder pain, depending on the concurrent disease and associated risk factors. Material and methods. We included in our retrospective study 40 consecutive patients that presented with shoulder pain, during the past 6 months, in the Department of Rheumatology. All those patients underwent ultrasound evaluation according to EULAR Guidelines for musculoskeletal Ultrasound in Rheumatology. Results. Rotator cuff lesions, which most commonly underlie non traumatic pain in adults, were detected with frequencies similar to the ones described by the literature. It seems that comorbidities, as the presence of diabetes, may influence tendon degeneration or rupture. Conclusions. Although it included a relatively low number of subjects, our paper reveals data similar to the ones previously published and underlines the necessity of applying an algorithm for managing shoulder pathology, that should mandatory include ultrasonography examination, in order to obtain an accurate diagnosis and individualize each patient's therapeutic approach and improve their life quality.

show abstract

The Relationship between the Acute Confusing State and the Comorbidities of the Elderly Patient

Cited by 4 publications

References 27 publications

Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives

Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives

Oxidative Stress and Antioxidant Defense Mechanisms in Acute Ischemic Stroke Patients with Concurrent COVID-19 Infection

Shoulder Involvement in Daily Practice – Ultrasonographic Approach

Contact Info

Product

Resources

About