Background: Preterm prelabour rupture of the fetal membranes (PPROM) complicates 3% to 4% of all pregnancies. It is responsible for 40% of all preterm births with its attendant high perinatal morbidity and mortality.Objective: The aim of this study was to determine the prevalence of PPROM; with profile and antibiotic susceptibility of isolated organisms.Methodology: It was a prospective study carried out between 10th July 2011 and 22nd August 2012 among recruited pregnant women that met the inclusion criteria. Collection of samples from the endocervix and posterior vaginal fornix by sterile speculum examination was done; with same processed using standard microbiological techniques.Results: Klessiella was the commonest organism isolated accounting for 32.1%, followed by Escherichia coli (19.6%); with highest sensitivity shown to ciprofloxacin (96.3%), and followed by amoxiclav (94.4%), ceftriazone (92.6%) and cefuroxime (90.6%).
Conclusion:Prophylactic use of antibiotics in the management of PPROM should largely be based on the demonstrated microbiological pattern and sensitivity in the environment in question.
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