Microbiological Pattern in Preterm Prelabour Rupture of the Fetal Membranes in South-Western Nigeria

Adewumi, OA

doi:10.15406/ogij.2017.06.00215

Cited by 3 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A significant difference in the positive culture rates was found in the two comparison groups, which suggests a strong correlation between the infection of the genital tract and the occurrence of PPROM. A similar association was found in the study done by Adewumi et al 2 This study has reported E. coli to be the commonest organism isolated in 52.6% of the PPROM cases. It was also found to be the commonest organism in the reported literature contributing to 30-53% in the studies done over the past few years.…”

Section: Discussionsupporting

confidence: 89%

“…The positive culture rates in PPROM range from 21% and 45% according to the studies conducted by Shivaraju et al, 6 Adewumi et al, 2 Shilpa et al, 7 and Devi. 8 The findings obtained in this study also fall in this particular range.…”

Section: Discussionmentioning

confidence: 99%

“…It was also found to be the commonest organism in the reported literature contributing to 30-53% in the studies done over the past few years. 2,[5][6][7][8] According to the available data, it is quite evident that E. coli is consistently stable as the commonest organism isolated among the PPROM affected patients over time. Other common bacteria isolated were found to be Klebsiella and Enterococcus in this study as similarly seen in a few other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Various research projects conducted in India have reported the incidence of puerperal sepsis to be 17-20% and neonatal sepsis to be 20-22% in PPROM-complicating pregnancies. 2 Both gramnegative and positive bacteria are implicated in the causation of PPROM.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

Ghose,

Sravya,

Yogamoorthi

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Aim: This study was carried out to determine the vaginal bacteriological pattern along with their antibiotic susceptibility pattern in pregnant women with preterm prelabor rupture of membranes (PPROM) and to compare them with those without PPROM. The association of PPROM with neonatal and maternal complications was also studied. Materials and methods: This is an observational comparative study conducted in the year 2020 at a tertiary care teaching hospital located in Puducherry, India. The study included singleton pregnancies between 28 0/7 and 36 6/7 weeks of gestation with PPROM along with gestational age matched women without PPROM. A high vaginal swab was taken from all the candidates and sent for aerobic and anaerobic cultures. Organisms isolated along with their antibiotic susceptibility were noted and compared between the two groups. The software used was Statistical Package for the Social Sciences (SPSS) software, version 17.0 (IBM, Armonk, NY, USA). Results: This study demonstrated an overall incidence of PPROM of 2.8%. A positive culture rate of 35.2 and 9.3% was found among pregnant women with and without PPROM, which was found to be statistically significant. The commonest organism isolated was Escherichia coli (52.6%) which was 100% sensitive to imipenem and meropenem and 90% to cefoperazone-sulbactam and was found to be resistant to ampicillin in 90% of cases. Neonatal complications such as respiratory distress and sepsis were found to be significantly higher in the PPROM group than in the comparison group. Conclusion:There is no change in the vaginal microbiota in the last two decades, but the sensitivity pattern of antibiotics has changed considerably from the commonly used antibiotics to higher-generation antibiotics. This indicates indiscriminate use of antibiotics which has resulted in antibiotic resistance. This could be the probable reason for the increase in neonatal and maternal morbidity in PPROM. Clinical significance: The vaginal microbiological flora and the antibiotic susceptibility pattern of the population in this area was studied and a significant change was noted over the past years which will help in formulating newer and better treatment protocols in the future which would help in reducing neonatal and maternal morbidities.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

Ghose,

Sravya,

Yogamoorthi

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

show abstract

“…addition, there are risks associated with chorioamnionitis and placental abruption. 2 Group B Streptococcus (GBS) is the main pathogen which has been observed in lots of western maternal genital tract in PPROM cases. But some studies in other countries have demonstrated completely different results which showed the presence of other microorganisms as the main pathogens of PPROM.…”

mentioning

confidence: 99%

High diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcome

Jhirwal,

Singh,

Shekhar

et al. 2024

Int J Community Med Public Health

View full text Add to dashboard Cite

Background: Premature rupture of the membranes (PROM) complicates 3% of pregnancies and its associated with adverse perinatal outcome. Methods: This was a case control study conducted over a period of two years. Our aim was to evaluate the bacterial colonization of genital tract of antenatal patients who presented with preterm premature rupture of membranes and their maternal and neonatal complications. We studied 6023 patients during our study period among which 156 patients presented with preterm premature rupture of membranes. Results: PPROM was found more commonly among age 25-30 years (46.79%) with p<0.001. Out of 156 pregnant women with PPROM, only 16 patients (10.26%) developed clinical chorioamnionitis. We observed that 43.59% patients (n=68) with PPROM underwent LSCS which was significantly higher than control group (19.93%). Among them 81.41% (n=127) of the patients delivered within 24 hours of admission. Among 156 patients, 94 (59.12%) mothers had babies with birth weight ranging between 1.5-2.5 kg as compared to control group where 30.51% mothers had low birth weight babies. The difference was statistically significant. Approximately 18.24% babies developed respiratory distress syndrome requiring ICU care in study group as compared to 3.03% in control group and the difference was statistically significant. Conclusions: It is important to diagnose the PPROM early and manage the patient until delivery for better outcome. Timely intervention after proper analysis of risk and benefit of early termination helps in reducing adverse perinatal outcomes, reduced NICU admissions and unnecessary interventions for neonates.

show abstract

Cervical amniotic fluid bacterial colonization, antibiotic susceptibility and associated factors among women with premature rupture of membranes at Mbarara Regional Referral Hospital, Southwestern Uganda

Ainomugisha

Bazira

Agaba

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Bacterial colonization is a recognized cause of premature rupture of membranes (PROM), a predictor of poor maternal and fetal outcomes. Despite routine use of antibiotics in women with PROM, data on antibiotic susceptibility patterns in Uganda are limited. We determined the prevalence and associated factors of cervical amniotic fluid bacterial colonization, and described the bacterial isolates and antibiotic susceptibility patterns among women seeking care at Mbarara Regional Referral Hospital (MRRH) in Southwestern Uganda. Methods We conducted a cross-sectional study at MRRH from December 21, 2020 to June 12, 2021. We consecutively enrolled women with PROM at ≥ 24 weeks of gestation, and aseptically picked two endo-cervical swabs irrespective of prior antibiotic use. Aerobic cultures were performed on blood, chocolate, MacConkey agars and incubated at 35–37◦C for 24–72 hours. Polymerase chain reaction (PCR) was performed on culture-negative samples. Antibiotic susceptibility was performed via Kirby-Bauer disk diffusion and dilution method. Interviewer-administered questionnaires were used to obtain participants’ characteristics. We performed multivariable logistic regression to determine factors associated with bacterial colonization. Results We enrolled 144 participants with mean age of 26.5 ± 6.2 years. Prevalence of cervical amniotic bacterial colonisation was 35.4% (n = 51; 95%CI: 28.0–43.7). Six bacteria were isolated: Klebsiella pneumoniae (n = 15; 34.1%), Staphylococcus aureus (n = 11; 25.0%), Enterobacter agglomerans (n = 10; 22.7%), Escherichia coli (n = 3; 6.8%), Streptococcus spp (n = 3; 6.8%), and Enterococcus faecalis (n = 2; 4.6%). Ciprofloxacin exhibited the highest sensitivity (88.6%), followed by cefuroxime (75%), while all isolated bacteria demonstrated resistance to ampicillin. Factors independently associated with cervical amniotic fluid bacterial colonisation were prime gravidity (aOR = 2.69; 95%CI: 1.07–6.71, p = 0.035), obesity (aOR = 3.15; 95%CI: 1.10–9.11, p = 0.024) and being referred-in (aOR = 2.37; 95% CI: 1.04–5.3, p = 0.038). Conclusion Approximately one-third of the women had cervical amniotic fluid bacterial colonization, with all the bacterial isolates being resistant to ampicillin —the recommended first line of treatment for PROM by the Ministry of Health. There is a need to review the guidelines for the prophylactic use of ampicillin in PROM in our setting. Revising treatment protocols and considering alternative antibiotics based on local resistance patterns could improve patient outcomes and prevent complications associated with ineffective antibiotic therapy in the context of PROM.

show abstract

Microbiological Pattern in Preterm Prelabour Rupture of the Fetal Membranes in South-Western Nigeria

Cited by 3 publications

References 22 publications

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

Vaginal Bacteriological Pattern in Women with and without Preterm Prelabor Rupture of Membranes: A Comparative Study

High diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcome

Cervical amniotic fluid bacterial colonization, antibiotic susceptibility and associated factors among women with premature rupture of membranes at Mbarara Regional Referral Hospital, Southwestern Uganda

Contact Info

Product

Resources

About