Preliminary data indicate that increased blood plasma level of β-endorphin in patients with nonpsychotic unipolar depression after 2 weeks of treatment correlates with the positive response to therapy. This parameter can be regarded as an objective indicator of potential improvements. Further studies aimed at determining the value of blood β-endorphin levels in patients with mood disorders for the diagnostics and estimating the therapeutic success in this disease are required.
Цель исследования: изучение различий в активности мозга у пациентов с депрессивным эпизодом в рамках рекуррентной (РД) и биполярной депрессии (БД). Дизайн: контролируемое нерандомизированное экспериментальное исследование. Материалы и методы. Выделены три группы: с РД (n = 16; 10 женщин), БД (n = 16; 8 женщин) и здоровых добровольцев (n = 16; 9 женщин). Группы пациентов с депрессией не получали лекарств и не различались по шкалам тревоги и депрессии Гамильтона. Испытуемые сортировали 160 фотографий людей и животных: на 80 снимках были представлены нейтральные образы, на 80-образы злых/агрессивных людей и животных. Простые фигуры (ключи) подавались за 2 сек до картинок, их связь с фотографиями не объяснялась. Выполняли запись 128-канальной электроэнцефалограммы и анализ вызванных ключом ответов мозга. Получили разностные волны между нейтральными и эмоциональными условиями (эмоциональную модуляцию-ЭМ) и проводили их попарные сравнения между группами испытуемых. Результаты. Обнаружены статистически значимые различия в компоненте Р100 в задних отделах мозга между пациентами с депрессией и контролем (p < 0,05). ЭМ компонентов N150, P220 и P380 проявила специфичность относительно группы и типа стимулов. Заключение. Неосознанная ЭМ определенных компонентов вызванной активности мозга может быть перспективным биомаркером для различения РД и БД. Ключевые слова: электроэнцефалограмма, рекуррентная депрессия, биполярная депрессия, имплицитный, лицевая экспрессия.
The properties of albumin binding sites in patients before and after treatment differed from those in controls. The authors suggest that it points to the changes in albumin molecule conformation that may influence the functional state of the protein. It has been suggested that these changes may be considered as biomarkers of pharmacotherapeutic efficacy.
IntroductionImportance of current research is determined by the need to find the clinical and functional evaluation criteria for the systemic patterns of changes in physiological reactivity of the patient at various stages depression treatment.ObjectiveOptimization of diagnostics and planning of treatment of patients with depression based on analysis psychopathological state and autonomic reactivity during active treatment using SSRI antidepressants.AimsSystem analyze of clinical-psychopathological characteristics and autonomic reactivity of major depression. Main group included 62 patients with the diagnosis of depressive episode. Control group: 64 healthy persons.MethodsClinico- psychopathological, clinico- anamnestic, Hamilton Depression Rating Scale (HDRS-17), the analysis of heart rate variability for investigation of autonomic regulation.Results of the depressive patients autonomic regulation study show the reduction of total heart rate variability is observed at rest and in orthostatic test. The balance of sympathetic, parasympathetic and suprasegmental parts of autonomic nervous system was preserved at rest in depression. However after orthostatic test the activity of sympathetic baroreflex mechanisms is decreased and the hyperactivation of suprasegmental ergotropic systems is revealed. During the 4–6-weeks treatment the positive dynamics of psychopathological characteristics is observed but the changes of autonomic reactivity are not revealed. After 6-months therapy only 30, 6% of patients demonstrate signs of normalisation of autonomic regulation.ConclusionsObtained data, apparently, attest to the fact that the emotional and autonomic symptoms are restored with different speed. The results of study should be used in the planning of treatment in the psychiatric practice and in the primary medical care.
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