Emotional Modulation of Visual Brain Responses during Classical Conditioning in Patients with Recurrent vs. Bipolar Depressio

Mnatsakanian, Elena; Kryukov, V.V.; Antipova, O.S.; Краснов, В.

doi:10.31550/1727-2378-2019-161-6-47-52

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…Для каждой из четырех категорий был свой ключпростая фигура. Более подробно стимулы и дизайн исследования описаны в наших работах [11,12].…”

Section: стимулы и общий план исследованияunclassified

“…Топография ЭМ для двух групп контроля была схожей, у РДМ она не определялась, у РДЖ отличалась от нормы. Это соответствует полученным нами ранее результатам на смешанной группе пациентов [12].…”

Section: результаты и обсуждениеunclassified

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Gender-related Differences in Emotional Modulation of Visual Brain Responses in Patients with Recurrent Depression

Mnatsakanian¹,

Kryukov²,

Краснов³

et al. 2020

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Study Objective: To study gender-related characteristics of brain activity in patients with recurrent depression, while they perform a cognitive task with emotional stimulation. Study Design: This was a controlled non-randomized experimental study. Materials and Methods: Four groups were formed: two groups consisted of patients with recurrent depression (24 men and 24 women) and two groups were made up of healthy volunteers (25 men and 25 women). The patients were not taking any medications and did not differ in their Hamilton Depression Rating Scale or Hamilton Anxiety Rating Scale scores. The subjects were asked to sort 160 photos of people or animals, of which 80 were neutral images and 80 showed angry/aggressive people or animals. Simple patterns (cues) were presented two seconds prior to the pictures, and their relationship with the photographs was not explained. A 128-channel electroencephalogram was recorded and cue-elicited brain responses analyzed. Differences between the neutral and emotional conditions (emotional modulation, EM) were statistically evaluated for each group. Study Results: Gender-related differences in EM were greater in the patients than in the control-group subjects. The male patients had no EM of the P100 component, while EM of the P200 component and slow-wave activity after 400 msec was partially absent. In the female patients EM was consistently observed in the right posterior cortex. There were minimal differences in topographic distribution of EM of the N170 and P380 components between men and women as well as between patients and healthy subjects. Conclusion: Gender-related differences in unconscious EM of certain components of evoked brain activity suggest that mechanisms involved in the processing of emotional information are somewhat different in men and women. This suggests a need for a differentiated approach to examination and treatment of patients. Keywords: emotional modulation, electroencephalogram, recurrent depression, implicit education, visual evoked potentials, facial expression, anger.

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Section: стимулы и общий план исследованияunclassified

Section: результаты и обсуждениеunclassified

Gender-related Differences in Emotional Modulation of Visual Brain Responses in Patients with Recurrent Depression

Mnatsakanian¹,

Kryukov²,

Краснов³

et al. 2020

Self Cite

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“…Consequently, EEG parameters can be useful as biological markers of a mental illness that trace back to specific pathophysiological mechanisms. Data accumulated to date from high-caliber studies [10-12] , including the results of our own studies [13,14] , suggest various EEG markers that can be used to differentiate between unipolar and bipolar depression. However, the question of how well they hold up to scrutiny remains open.…”

Section: Introductionmentioning

confidence: 96%

“…According to some studies, the quantitative characteristics of the alpha rhythm can only be fully understood after one takes into account the spectral power and activation intensity (inhibition of the alpha rhythm after one opens their eyes, the Berger effect) [18,19] . Considerable data now exists on the changes that take place in the alpha power in depressive disorders of various origins [10-17] . However, only a few studies into the activation reaction in patients with depressive disorders can be found in the literature [20] .…”

Section: Introductionmentioning

confidence: 99%

EEG alpha band characteristics in patients with a depressive episode within recurrent and bipolar depression

Bokhan,

Galkin,

Vasilyeva

2023

Consortium Psychiatricum

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INTRODUCTION: The search for biological markers of differential diagnosis of recurrent and bipolar depression is one of the main tasks in modern psychiatry. To solve this problem, one of the promising tools is electroencephalography. OBJECTIVE: To identify differences in the digital parameters of the a-rhythm of the electroencephalogram in patients with a depressive episode within the framework of recurrent and bipolar depression. METHOD: Two groups of patients (women) were identified: with recurrent depressive disorder, the current episode of mild/moderate severity (47 patients) and with bipolar affective disorder, the current episode of mild or moderate depression (30 patients). The groups of patients did not receive pharmacotherapy and did not differ in socio-demographic indicators and the Hamilton depression scale. A background electroencephalogram was recorded and the quantitative characteristics of the -rhythm were analyzed: absolute spectral power, microstructure of the -spindle, activation reaction. RESULTS: In patients with bipolar affective disorder, compared with patients with recurrent depression, statistically significantly higher indicators of the absolute spectral power of the -rhythm were found in the parietal-occipital and posterior temporal leads (p 0.05), accelerated type of -rhythm was more often detected (20% vs. 2.1%; p = 0.024), the degree of depression of the -rhythm when opening the eyes in the parietal and posterior temporal leads (p 0.05). CONCLUSION: The presented quantitative characteristics of -activity confirm that patients with affective disorders of various genesis have their own distinctive electrophysiological features that can become promising biomarkers for distinguishing bipolar and recurrent depression.

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Emotional Modulation of Visual Brain Responses during Classical Conditioning in Patients with Recurrent vs. Bipolar Depressio

Cited by 2 publications

References 19 publications

Gender-related Differences in Emotional Modulation of Visual Brain Responses in Patients with Recurrent Depression

Gender-related Differences in Emotional Modulation of Visual Brain Responses in Patients with Recurrent Depression

EEG alpha band characteristics in patients with a depressive episode within recurrent and bipolar depression

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