The present study is an attempt at a morphofunctional systematic approach to such important problems as the interrelationship of voluntary and involuntary activity, conscious and unconsciolas processes in the brain, and the individuality of the personality.Two factors underlie such an examination: 1) the principles of structural interrelationships between the basic brain systems, sensory, associative, integrative-actuating (motorie), on the one hand, and the limbicoreticular, on the other (as we know, the latter are especially closely associated with the processes of motivations and emotions; 2) the presence in the socalled "core of the brain," mainly in the limbicoreticular formations, of special architectonics of many biologically active substances, the neurotransmitters, neurohormones, neuropeptides, which support such extremely important psychological functions as perception, memory, cognitive and motoric activity [42, 43, 46, etc.].We are advancing a number of theses regarding possible pathways of the interactions of these extremely important aspects of the integrative activity, and, not by accident, dwelling on an analysis of the direct anatomical and neurochemical associations between brain structures, taking the complexity of the problem of multisynaptic relationships into accot~nt.The organization of motivations and emotions is based on the principle of their quite broad territorial (multiple) representation in the region of the stem, diencephalon, and telencephalon. Since these concepts are psychophysiological categories, the question arises: to what extent can one speak of the structural-functional organization of these states? In a conception of the principles of the organization of the integrative activity of the brain [1-3], we have attempted to provide a positive response in relation to the organization of such functions as perception, cognitive processes, memory and motorie activity. The very same principles may evidently be included in notions regarding the pathways and mechanisms of the interaction and mutual cooperation of the functions noted above with the motivational principle, and not infrequently, emotional accompaniment, present in them [7, 11, 16, 28, 29, etc.]. It should be taken into account that these processes are always based to one degree or another on the dominant formed in each concrete instance as the working principle of the neural centers [33]. The understanding of the common principles of the interaction of functions may prove promising in the solution of such problems as the architecture of the brain, the individuality of the personality, the interrelation of conscious and unconscious forms of activity, etc.