Method of local application of focused ultrasound to deep brain structures of an unrestrained unanesthetized animal

Adrianov, O. S.; Vykhodtseva, Natalia; Фокин, В. Ф.; Avirom, V. M.

doi:10.1007/bf00806331

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…Furthermore, mechanical energy from ultrasound could temporarily disrupt delicately organized synaptic signalosomes within the postsynaptic density. Adrianov et al 1 used electron microscopy to analyze the effects of low-intensity ultrasound on the feline lateral geniculate nucleus and found widening of the synaptic cleft and a decrease in the thickness of the postsynaptic density. Given the relatively long-lasting effects we observed after LIFU sonication of the ventrolateral thalamus, it is tempting to speculate that prolonged ultrasound exposures could lead to some form of shortterm synaptic plasticity.…”

Section: Mechanism Of Lifu Neuromodulationmentioning

confidence: 99%

“…1,13,15,16 During the 1950s, high-intensity focused ultrasound (HIFU) was used experimentally to reversibly inhibit neuronal activity through moderate heating below the threshold for tissue ablation, 14 and it was used clinically to treat patients with movement disorders and brain tumors. 17,27 Advances in noninvasive, transcranial delivery of ultrasound over the past 15 years have renewed an interest in its use for neurosurgical applications.…”

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confidence: 99%

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Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Dallapiazza¹,

Timbie

Holmberg

et al. 2018

Journal of Neurosurgery

187

175

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OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal. METHODS Ten Yorkshire swine ( Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage. RESULTS LIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage. CONCLUSIONS These results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

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Section: Mechanism Of Lifu Neuromodulationmentioning

confidence: 99%

mentioning

confidence: 99%

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Dallapiazza¹,

Timbie

Holmberg

et al. 2018

Journal of Neurosurgery

187

175

View full text Add to dashboard Cite

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“…FUS can produce similar effects in the brain (in particular, the optic nerve) as seen in peripheral nerves (Fokin et al 1979;Adrianov et al 1984b;Adrianov et al 1984a) (Adrianov et al 1984c;Vykhodtseva et al 1976;Adrianov et al 1984d). Suppression of the visual evoked potential (VEP) in both the optic nerve and visual cortex was obtained by sonications of the optic nerve in the area of its junction with the lateral geniculate nucleus.…”

Section: Introductionmentioning

confidence: 99%

Focused Ultrasound Effects on Nerve Action Potential in vitro

Colucci

Strichartz

Jólesz

et al. 2009

Ultrasound in Medicine & Biology

140

123

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Minimally invasive applications of thermal and mechanical energy to selective areas of the human anatomy have led to significant advances in treatment of and recovery from typical surgical interventions. Image-guided focused ultrasound allows energy to be deposited deep into the tissue, completely noninvasively. There has long been interest in using this focal energy delivery to block nerve conduction for pain control and local anesthesia. In this study, we have performed an in vitro study to further extend our knowledge of this potential clinical application. The sciatic nerves from the bullfrog (Rana catesbeiana) were subjected to focused ultrasound (at frequencies of 0.661MHz and 1.986MHz) and to heated Ringer’s solution. The nerve action potential was shown to decrease in the experiments and correlated with temperature elevation measured in the nerve. The action potential recovered either completely, partially, or not at all, depending on the parameters of the ultrasound exposure. The reduction of the baseline nerve temperature by circulating cooling fluid through the sonication chamber did not prevent the collapse of the nerve action potential; but higher power was required to induce the same endpoint as without cooling. These results indicate that a thermal mechanism of focused ultrasound can be used to block nerve conduction, either temporarily or permanently.

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“…The temperature increase did not exceed fractions of a degree, which excluded heat from the main factors affecting the visual tract. An experiment [28] is important from the methodological point of view. In this experiment, a unit with a built in relatively small (diameter 18 mm) focusing transducer was fixed on the head of an animal in such a way that the focal region of the transducer was aligned with a targeted exposure site.…”

Section: Focused Ultrasound As a Tool To Input Sensory Information Tomentioning

confidence: 99%

“…The study was developed in two directions. The first direction was related to reversible shutdown of the visual function under the effect of focused ultrasound in animals [28][29][30]. The changes in the evoked potentials recorded in the visual tract and visual cortex under the action of light stimulation of eyes were studied in cats.…”

Section: Focused Ultrasound As a Tool To Input Sensory Information Tomentioning

confidence: 99%

Focused ultrasound as a tool to input sensory information to humans (Review)

Гаврилов

Tsirulnikov

2012

Acoust. Phys.

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This review is devoted to the analysis of studies and implementations related to the use of focused ultrasound for functional effects on neuroreceptor structures. Special attention was paid to the stimulation of neuroreceptor structures in order to input sensory information to humans. This branch of medical and phys iological acoustics appeared in Russia in the early 1970s and was being efficiently developed up to the late 1980s. Then, due to lack of financial support, only individual researchers remained at this field and, as a result, we have no full fledged theoretical research and practical implementations in this area yet. Many promising possibilities of using functional effects of focused ultrasound in medicine and physiology have remained unimplemented for a long time. However, new interesting ideas and approaches have appeared in recent years. Very recently, very questionable projects have been reported related to the use of ultrasound for targeted functional effects on the human brain performed in some laboratories. In this review, the stages of the development of scientific research devoted to the functional effects of focused ultrasound are described. By activating the neuroreceptor structures of the skin by means pulses of focused ultrasound, one can cause all the sensations perceived by human beings through the skin in everyday life, such as tactile sensations, ther mal (heat and cold), tickling, itching, and various types of pain. Stimulation of the ear labyrinth of humans with normal hearing using amplitude modulated ultrasound causes auditory sensations corresponding to an audio modulating signal (pure tones, music, speech, etc.). Activation of neuroreceptor structures by means of focused ultrasound is used for the diagnosis of various neurological and skin diseases, as well as hearing dis orders. It has been shown that the activation is related to the mechanical action of ultrasound, for example, by the radiation force, as well as to the direct action of ultrasonic vibrations on nerve fibers. The action of the radiation force is promising for the realization of the possibility of blind and even deaf and blind people to perceive text information on a display using tactile sensations caused by ultrasound. Very different methods of using ultrasound for local stimulation of neuroreceptor structures are discussed in this review. Among them are practical methods that have been already tested in a clinic, as well as pretending to be sensational methods that are hardly feasible in the foreseeable future.

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Method of local application of focused ultrasound to deep brain structures of an unrestrained unanesthetized animal

Cited by 7 publications

References 2 publications

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Focused Ultrasound Effects on Nerve Action Potential in vitro

Focused ultrasound as a tool to input sensory information to humans (Review)

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