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The aim of the study was to evaluate two essentially different methods of assessing differences in children's taste preferences with regard to five different paediatric penicillin formulations. The study was performed with a parallel group design comparing five groups. A taste evaluation was recorded in 103 children with upper respiratory tract infections after a single therapeutic test dose. First the patient's own spontaneous verbal judgement was recorded then a judgement was arrived at using a hedonic scale of facial expressions. Both judgements were passed immediately and also 3-4 minutes after the test dose. In the children who were 6 years of age or younger, a better discrimination of taste differences between formulations was achieved by using the patients' own spontaneous verbal judgements instead of the facial hedonic method. Both methods seem appropriate in older children, but the hedonic scale is preferable since its use implies a more standardised procedure.

Total ablation of the pinna gives an unsatisfactory cosmetic result which has to be corrected. Plastic surgery procedures are generally not very successful and some sort of episthesis is preferred by many. The attachment of an episthesis is, however, often a problem. This paper is a case report of a new type of episthesis fixation arrangement. In a first session four titanium screws were implanted into the temporal bone above and behind the external meatus with a technique ensuring minimal tissue violation. Three months later when these screws were firmly integrated in the living bone, skin‐penetrating titanium abutments were connected and a gold bridge was adapted to the abutments. A silicon rubber episthesis was attached to the bridge with a snap fastener. Behind this new method of episthesis attachment are several years of clinical experience of titanium implants directly anchored into various living bones and allowed to permanently penetrate skin or mucous membrane.

A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was found to be influenced by changes in the bacterial incubation medium and growth phase, the concentration of bacteria and epithelial cells, the epithelial cell donor, the incubation time and temperature, and the pH and osmolarity of the incubation medium. Pretreatment of bacteria with heat, Formalin, or trypsin decreased adhesion. The highest adhesion was obtained when 109 bacteria cultivated for 18 h in streptococcus cultivation broth were added to 104 pharyngeal cells and incubated at 37°C for 30 min. S. pneumoniae strains from patients with frequent episodes of otitis media and strains from healthy carriers had the highest adhesion values; septicemia and meningitis strains had the lowest. The capsular polysaccharide type did not determine the adhesive capacity of the strains, but otitis strains belonging to the capsular types often associated with otitis media adhered in high numbers. Adhesion may be important for pneumococci colonizing the nasopharynx or inducing otitis media. strains were isolated from the blood of patients with 311 on August 5, 2020 by guest http://iai.asm.org/ Downloaded from