BackgroundIntense ultrasound, such as that used for tumor ablation, does not differentiate between cancerous and normal cells. A method combining ultrasound and biocompatible gold or magnetic nanoparticles (NPs) was developed under in vitro conditions using human breast and lung epithelial cells, which causes ultrasound to preferentially destroy cancerous cells.ResultsCo-cultures of BEAS-2B normal lung cells and A549 cancerous lung cells labeled with green and red fluorescent proteins, respectively, were treated with focused ultrasound beams with the addition of gold and magnetic nanoparticles. There were significantly more necrotic A549 cells than BEAS-2 cells when gold nanoparticles were added to the culture medium [(50.6 ± 15.1) vs. (7.4 ± 2.9) %, respectively, P < 0.01]. This selective damage to cancer cells was also observed for MDA-MB231 breast cancer cells relative to MCF-10A normal breast cells after treatment with magnetic nanoparticles.ConclusionsThe data obtained for different cell lines indicate that nanoparticle-assisted ultrasound therapy (NAUT) could be an effective new tool for cancer-specific treatment and could potentially be combined with conventional methods of cancer diagnosis and therapy to further increase the overall cancer cure rate.
It is shown that a specific form of the electric discharge with bulk glow in the entire space between electrodes and an increasing current-voltage characteristic inherent to the anomalous glow discharge in gas can exist in a liquid exposed to an intense ultrasonic field above the cavitation threshold. Such a discharge can be initiated between planar or rod electrodes in liquid in the mode of developed cavitation excited by an ultrasonic acoustic field. It is found that a plasma pinch is formed during cavitation between electrodes immersed into liquid. The pinch is stable at relatively low voltages (∼30-60 V) and currents (4-8 A).
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