Selective killing of cancer cells by nanoparticle-assisted ultrasound

Kosheleva, O. K.; Lai, Tsung‐Ching; Chen, Nelson G.; Hsiao, Michael; Chen, Chung-Hsuan

doi:10.1186/s12951-016-0194-9

Cited by 55 publications

(29 citation statements)

References 21 publications

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“…The result is a mechanical damage and a consequent induction of cell death by the so called "mechanical pathway" from refs. [88,105], as also depicted in Fig. 3.…”

Section: G Canavese Et Alsupporting

confidence: 57%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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“…The result is a mechanical damage and a consequent induction of cell death by the so called "mechanical pathway" from refs. [88,105], as also depicted in Fig. 3.…”

Section: G Canavese Et Alsupporting

confidence: 57%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

View full text Add to dashboard Cite

show abstract

“…Gold NPs have been tested as drug carriers, [6] and radio-sensitizers. [7] The gold NPs can simultaneously be used to visualize their location inside the body using photoacoustic imaging, [8] or optical coherence tomography, [9] in combination with X-ray imaging, [10] or electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Nanoparticle-Assisted Ultrasound for Cancer Therapy

Kosheleva¹,

Chen²,

Lai³

et al. 2017

JBiSE

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“…There are several examples in the literature that have proved the utility of a CAD system in ultrasound. The wide range of use has made it useful in breast lesion interpretation [19], quantifying liver steatosis [20] and even in assisting "killing" the cancer cells [21].…”

Section: Discussionmentioning

confidence: 99%

Is Contrast Enhanced Ultrasonography a useful tool in a beginner’s hand? How much can a Computer Assisted Diagnosis prototype help in characterizing the malignancy of focal liver lesions?

et al. 2017

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Aim: Contrast enhanced ultrasound (CEUS) improved the characterization of focal liver lesions (FLLs), but is an operatordependent method. The goal of this paper was to test a computer assisted diagnosis (CAD) prototype and to see its benefit in assisting a beginner in the evaluation of FLLs.Material and method: Our cohort included 97 good quality CEUS videos[34% hepatocellular carcinomas (HCC), 12.3% hypervascular metastases (HiperM), 11.3% hypovascular metastases (HipoM), 24.7% hemangiomas (HMG), 17.5% focal nodular hyperplasia (FNH)] that were used to develop a CAD prototype based on an algorithm that tested a binary decision based classifier. Two young medical doctors (1 year CEUS experience), two experts and the CAD prototype, reevaluated 50 FLLs CEUS videos (diagnosis of benign vs. malignant) first blinded to clinical data, in order to evaluate the diagnostic gap beginner vs. expert. Results: The CAD classifier managed a 75.2% overall (benign vs. malignant) correct classification rate. The overall classification rates for the evaluators, before and after clinical data were: first beginner-78%; 94%; second beginner-82%; 96%; first expert-94%; 100%; second expert-96%; 98%. For both beginners, the malignant vs. benign diagnosis significantly improved after knowing the clinical data (p=0.005; p=0,008). The expert was better than the beginner (p=0.04) and better than the CAD (p=0.001). CAD in addition to the beginner can reach the expert diagnosis. Conclusions: The most frequent lesions misdiagnosed at CEUS were FNH and HCC. The CAD prototype is a good comparing tool for a beginner operator that can be developed to assist the diagnosis. In order to increase the classification rate, the CAD system for FLL in CEUS must integrate the clinical data.

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Selective killing of cancer cells by nanoparticle-assisted ultrasound

Cited by 55 publications

References 21 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

RETRACTED: Nanoparticle-Assisted Ultrasound for Cancer Therapy

Is Contrast Enhanced Ultrasonography a useful tool in a beginner’s hand? How much can a Computer Assisted Diagnosis prototype help in characterizing the malignancy of focal liver lesions?

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