В соответствии с современными представлениями о рассеянном склерозе (РС), значительную роль в развитии патологического процесса играют B-лимфоциты. В связи с этим имеет значение поиск новых биомаркеров В-лимфоцитарного происхождения, которые могут отражать клинические особенности этого заболевания. Цель работы-оценить соотношение между уровнем 48 кДа формы неконвенционного миозина 1с (48 кДа Myo 1c) в сыворотке крови больных рассеянным склерозом и стадией этого заболевания, его тяжестью и типом течения.
Background. Sexual dysfunction is a common problem in women with multiple sclerosis (MS). The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a specific instrument to evaluate sexual dysfunction in MS patients. The purpose of the study was to translate and validate the Ukrainian version of the MSISQ-19. Materials and methods. The original version of MSISQ-19 was translated under a standard procedure. A sample of 126 females with MS completed the questionnaire. Internal consistency was evaluated using Cronbach's alpha. Convergent validity was established using correlation with the Multiple Sclerosis Quality of Life-54 (MSQOL-54) and the Expanded Disability Status Scale (EDSS). Results. Total scale reliability (Cronbach's α = 0.943) and reliability for the primary (Cronbach's α = 0.901), secondary (Cronbach's α = 0.875), and tertiary subscales (Cronbach's α = 0.918) were high. Disability level, measured with the EDSS, and quality of life, measured with the MSQOL-54, significantly correlated with MSISQ-19 total score. Both physical and mental health-related quality of life on the MSQOL-54 significantly correlated with MSISQ-19 total score, and with primary, secondary, and tertiary sexual dysfunction. Satisfaction with sexual function significantly correlated with MSISQ-19 total score, and with primary, secondary, and tertiary sexual dysfunction. Conclusions. The study findings suggest that the Ukrainian version of the MSISQ-19 is a reliable and valid instrument for sexual function assessment in Ukrainian women with MS. It can be used during routine counseling to introduce the theme of sexuality, to detect sexual dysfunction, provide treatment, and prevent the development of more severe problems and therefore preserve the proper quality of life for MS patients.
Despite a lot of studies of sexual dysfunction there are still no consistent data about the prevalence and characteristics of sexual dysfunction among women with MS, especially it terms of multiple sclerosis severity and duration. The objective: was to determine the prevalence of various SD symptoms among female MS patients, depending on the age and severity of the disease, and evaluate SD impact on quality of life. Materials and methods. The study population includes 116 female patients with MS (McDonald’s criteria, 2010). Health – related quality of life was measured by the Multiple Sclerosis Quality of Life Questionnaire (MSQOL-54). Sexual dysfunction was assessed with the Sexual Function Index for Women with Multiple Sclerosis Questionnaire. Results. A direct average correlation between satisfaction with sexual life and relationships; sexual activity and arousal; discomfort and pain during sexual intercourse; direct impact of multiple sclerosis on sexual life and total quality of life, physical health component, mental health component was established (р<0.05). The prevalence of sexual dysfunction increases with the age and disease duration. Conclusions. Our data confirm that SD is common symptom in women with MS and significantly affect their quality of life. Key words: multiple sclerosis, female sexual dysfunction.
The use of a reliable safe method of contraception is important for women with multiple sclerosis. Proper and systematic use of reliable methods of contraception should be followed to avoid the need for abortion or the risk of giving birth to a child with developmental disabilities. At the same time, the use of contraception in women with MS has certain features, which determines the importance of studying the problem. The objective: to investigate the use of drugs to prevent unwanted pregnancies among women with multiple sclerosis. Materials and methods. The level of use of various contraceptive methods in women with multiple sclerosis and features of contraception in this category of patients are analyzed. Results. 35.3% of women with MS use contraceptive methods. The most common method is barrier (condoms) – 32.8%. With age, the frequency of contraceptive use in women with MS decreases and in the age group of 39–49 years, the vast majority of women (85.7%) do not use any methods of contraception. Conclusions. The critically low level of contraceptive use among women with MS increases the risk of adverse effects, including the birth of a sick child or the deterioration of a woman’s condition due to abortion. An informed choice of contraceptives is important in providing quality comprehensive care. Keywords: contraception, multiple sclerosis.
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