A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-containing liposomes without prior drying prevented a significant decrease in antibiotic content in unilamellar and multilamellar vesicles over a 3-month period at -70 degrees C.
Patients in surgical clinics who have undergone a variety of operations, the personnel in these clinics, along with the personnel in clinics of internal medicine, have been screened for potentially pathogenic bacteria carried in their orophyrangeal and nasal secretions and on their hands. 58% of the patients, 54% of those in the surgical clinics and 52% of the personnel in the clinics of internal medicine were found to be carriers. A relatively high rate of carriers of potentially pathogenic gram-negative rods was found in the hospital environment. Except for proteus, no significant pattern was observed with regard to distribution of bacteria among the various groups. Antibiotic resistance of S. aureus and S. albus haemolyticus strains isolated in the hospital environment was found to be higher in strains from patients than in those from personnel. It was found that 14% of typable S. aureus strains were in group I, 39% in group II and 46% in group III.
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