Background: Rosacea is a frequently seen chronic disease. Certain allergens, some foods and beverages are known to trigger symptoms of rosacea. Objective: We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal population. Method: Fourty patients with rosacea and 40 healthy age and sex-matched volunteers were included in the study. From European standard patch test series, test units with nickel were applied on the skin of the upper back. According to the scheme of the International Contact Dermatitis Research Group (ICDRG), test results were evaluated at 48th, 72th and 96th hours. Seven days later, reevaluation was done for late reactions. Statistical analyses were done by using Statistics package for Social Sciences (SPSS) 17 package program and p<0.05 was accepted as statistically significant. Results: Female/male ratio was 34/6 in patient group and 32/8 in control group. Mean age of the patient group and the control group were 39.97±12.65 (18-65 years), 40.82±11.79 (19-68 years), respectively. Age and sex distributions were found to be statistically similar. Nickel allergy in the patient and control group was found to be 52.5%, 22.5% respectively and the difference between groups was statistically significant (p=0. 006). Conclusion: Our results showed that there may be an association between nickel sensitivity and rosacea. Nickel sensitivity may be one of the underlying pathology or a triggering factor of the rosacea. Nickel restricted diet and avoiding the use of nickel-containing jewellery and piercings may extend the remission periods.

ÖZ GİRİŞ ve AMAÇ: Saç dökülmesinin pek çok formunda bazı vitaminlerin önemli rol oynadığı iyi bilinmektedir. Fakat vitamin B12 (vit B12) nin saç dökülmesinin ptogenezindeki rolü hala açık değildir. Bu çalışmada Kronik Tleogen Efluvium (KTE) ile vit B12 düzeyleri arasındaki ilişkiyi değerlendirmeyi amaçladık. YÖNTEM ve GEREÇLER: Dermatoloji polikliniğinde KTE tanısı alan hastalardan hasta grubu oluşturuldu. Kontrol grubu hiçbir sistemik ve dermatolojik hastalığı olmayan Vit B12 düzeyi check up polikliniğinde ölçülmüş olan bireylerden oluşturuldu. Her iki gruptaki bireyler için demogrfik özellikler ve vit B12 düzeyleri kaydedildi. İstatiksel analizler için SPSS 17 (Chicago, IL) paket programı kullanıldı. BULGULAR: Çalışma grubunda 317 hasta ve kontrol grubunda 327 sağlıklı birey vardı.Her iki grup yaş ve cinsiyet dağılımı açısından istatiksel olaak benzerdi. Ortalama vit B12 düzeyleri, hasta ve kontrol grupları için sırasıyla 345.72±138.39 pg/ml (255.14±102.13 pmol/l) ve 349.11±110.14 pg/ml (257.11±110.14 pmol/l) idi. Aradaki fark istatiksel olarak anlamsızdı (p> 0.05). Fakat vit B12 eksikliği hastaların 38 (11.98%)'inde kontrol grubunun ise 22 (6.72%)'sinde vardı. Aradaki fark istatiksel olarak anlamlıydı (p<0.05). TARTIŞMA ve SONUÇ: Vitamin B12 eksikliği oranı hasta grubunda belirgin derecede yüksek bulundu. Bizim sonuçlarımız, KTE ile vit B12 arasında bir ilişki olabileceğini gösteriyor.Anahtar Kelimeler: Telogen effluvium, vitamin B12, saç kaybı ABSTRACT INTRODUCTION: It is well known that some vitamins play a significant role in many forms of hair loss. However, the effect of vitamin B12 (vit b12) in the pathogenesis of hair loss is still unclear. We aimed to evaluate the relationship between vit B12 levels and Chronic Telogen effluvium (CTE) in this sudy. METHODS:Patient group was formed by the patients who had diagnosis of CTE in our dermatology outpatinet clinic. The control group was formed by individuals who had no systemic and dermatologic disease and whose vit B12 levels were measured at the check-up polyclinic. The demographic characteristics and the levels of serum vit B12 levels of the individuals were recorded for both groups. Statistical analysis was performed using SPSS 17 (Chicago, IL) pack program. RESULTS:There were 317 patients in the study group, 327 healthly individual in the control group. Both groups were statistically similar in terms of age and sex. Mean vit B12 levels of the patient and control group were 345. 72±138.39 pg/ml (255.14±102.13 pmol/l) and 349.11±110.14 pg/ml (257.11±110.14 pmol/l), respectively. The difference was statistically insignificant (p> 0.05). But vit B12 deficiency was found in 38 (11.98%) of the patients and in 22 (6.72%) of the controls. The differnece between groups was statistically significant. DISCUSSION AND CONCLUSION:Vitamin B12 deficiency rate was found to be significantly higher in our patient group.Our results indicate that there may be a correlation between CTE and vit B12 levels.

GİRİŞ ve AMAÇ: D vitamini, immünmodülatör ve antiinflamauvar etkilerinden dolayı deri hastalıklarıyla yakından ilişkilidir. Dermatolojik hasta grubumuzda D vitamini düzeylerini saptamak ve D vitamininin farklı dermatolojik hastalıklar üzerindeki etkisini değerlendirmek amacıyla bu çalışmayı yaptık.

elogen effluvium (TE), the loss of telogen hair that is first described by Kligman, is the most common cause of diffuse hair loss and it known as a hair cycle abnormality. 1,2 High fever, chronic systemic diseases, severe iron deficiency anemia and metabolic disorders such as liver