In our continuing interest on SarawakGarciniaspecies, we carried out the evaluation of antioxidant, anti-inflammatory and cytotoxic activities on the methanolic extracts ofGarcinia nervosa. The extracts were prepared from its air-dried grounded leaves and barks. The evaluation of antioxidant activities was done using the (2,2-diphenyl-1-picrylhydrazyl) DPPH radical scavenging assay and the result showed high radical scavenging activities. Meanwhile, the anti-inflammatory evaluation was performed using the lipoxygenase assay, hyaluronidase assay, and xanthine oxidase assay which showed, both of these extracts exhibited high anti-inflammatory properties. The lipoxygenase assay showed a high inhibition of enzyme activity for the barks extracts and a moderate enzyme activity for the leaves extracts. However, there were low inhibitions for both extracts in the hyaluronidase assay and only the barks extracts exhibited moderate antigout properties in the xanthine oxidase assay. For the cytotoxic assay, the extracts exhibited positive responses against the three cancer cell lines, the HeLa cell lines, MCF-7 cell lines, and HT-29 cell lines. Thus,Garcinia nervosacontains high antioxidativeand anti-inflammation properties, which have great potential in the development of pharmaceutical and dermatological products.
In Sarawak, Litsea garciae are known as "Engkala". The tree of 'Engkala' can grow in inland riparian forest and secondary forest. This medium-sized tree have long brittle spreading branches and the leaves lanceolate or obovate often with unequal side (asymmetric) and non-hairy. This seasonal fruit turn pink, or pinkish, greenish white when it is ripping depending on the variety. It is used as antidote against scorpion, centipede and snake bite by Bidayuh and Iban communities. It is also used to treat muscular pains, sprained ankles and knees, skin disease and blood in stools. The metanolic leaves, barks and fruits extracts of L. garciae were tested for its nutritional value, antioxidant and antibacterial activities. The nutritional values, such as N, P, K, Ca, Mg, Fe, Mn, Cu, Zn, B, moisture, ash, protein, carbohydrates and fat were determined based on MS677 and ICP-AES. The antioxidant assay was carried out using DPPH, free radical scavenging activity while the antibacterial assays were carried out using minimum inhibitory concentration (MIC) and disk diffusion method against five bacteria. The findings showed that L. garciae is a good source of carbohydrate and protein. In addition, it is also demonstrated weak activities towards antioxidant and antibacterial. The phytochemistry study on this plant is being carried out to identify bioactive compounds. Preliminary results suggest that L. garciae is rich in stearic acid. This common saturated fatty acids derived from plants may be used in the production of biodegradable soaps and cosmetics such as shampoo and shaving cream products.
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