Pharmacology evaluation of Litsea garciae (Lauraceae)

Kutoi, Clifford Junaidi; Khong, Heng Yen; Seruji, Nurr Maria Ulfa

doi:10.1109/beiac.2012.6226075

Cited by 3 publications

(5 citation statements)

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“…In this study, it was found that the results of anti-inflammatory activity of the methanolic extract of the leaves of Melicope ptelefolia (Tenggek burung) varied between two previous studies due to the different types of assays used by both studies: nitric oxide inhibition and soybean 15-lipoxygenase inhibition assays with the values of 95% and 72.3%, respectively [ 13 , 45 ]. Another study also reported that the anti-inflammatory activity of the methanolic extract of Litsea garciae fruits showed 9.42% (lipoxygenase assay) and 27.70% (hyaluronidase assay) [ 44 ]. Based on these results, it can be concluded that different assays used might produce different results.…”

Section: Discussionmentioning

confidence: 99%

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

Bakar

Abdullah

et al. 2018

Advances in Pharmacological Sciences

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This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti-inflammatory activity of Malaysian medicinal plants. The keyword search terms used were “inflammation,” “Malaysia,” “medicinal plants,” “mechanisms,” “in vitro,” and “in vivo.” As a result, 96 articles on anti-inflammatory activity of Malaysian medicinal plants were found and further reviewed. Forty-six (46) plants (in vitro) and 30 plants (in vivo) have been identified to possess anti-inflammatory activity where two plants, Melicope ptelefolia (Tenggek burung) and Portulaca oleracea (Gelang pasir), were reported to have the strongest anti-inflammatory activity of more than 90% at a concentration of 250 µg/ml. It was showed that the activity was mainly due to the occurrence of diverse naturally occurring phytochemicals from diverse groups such as flavonoids, coumarins, alkaloids, steroids, benzophenone, triterpenoids, curcuminoids, and cinnamic acid. Hence, this current review is a detailed discussion on the potential of Malaysian medicinal plants as an anti-inflammatory agent from the previous studies. However, further investigation on the possible underlying mechanisms and isolation of active compounds still remains to be investigated.

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Section: Discussionmentioning

confidence: 99%

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

Bakar

Abdullah

et al. 2018

Advances in Pharmacological Sciences

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“…The anticancer activity of L. garciae on human cell lines was investigated using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) method. Litsea garciae has moderate cytotoxic activities against three types of cell lines (Table 9) (Kutoi et al, 2012). The methanolic bark extract of L. garciae has moderate cytotoxic activities against human breast cancer (MCF-7) cell lines and human colorectal cancer (HT-29) cell lines with the IC 50 values of 66 and 77 μg/mL respectively, and weak cytotoxic activity against cervical cancer (HeLa) cell lines with IC 50 value of 117 μg/mL.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

“…To date, only one study was done to show the anti-inflammatory activity of L. garciae. A study by Kutoi et al (2012) shows the methanolic crude extracts of barks, leaves, and fruits of L. garciae exhibit some anti-inflammatory properties (Table 10). The bark, leaf, and fruit extracts inhibit lipoxygenase activity by 1.20%, 3.85%, and 9.42% respectively.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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A MINI REVIEW ON THE NUTRITIONAL COMPOSITIONS AND PHARMACOLOGICAL PROPERTIES OF Litsea garciae

Amit

ZINYIN

2021

MABJ

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Litsea garciae is an underutilized plant found in certain parts of South East Asia. The plant part has been traditionally used to treat, among others, skin infections, boil, rectal bleeding, muscular pain, and sprains. Besides its medicinal properties, its seasonal fruit is consumed for its avocado-like flavor. This article aims to provide information on what is known so far about the nutritional composition and pharmacological properties of Litsea garciae.

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The Genus Litsea: A Review of Its Cytotoxic Potential and Phytochemistry

Churi,

Khan

2024

IND. DRU.

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The family Lauraceae includes various genus in which Litsea has around 200-400 varieties which are widely scattered in the tropical and semi-tropical zones. In China, Litsea species are used traditionally in many disease conditions such as bone pain, diarrhoea, edema, dyspepsia, gastroenteritis and colds. Litsea glutinosa has been traditionally used in the treatment of tumors by the local people of Chittagong Hill Tracts, Bangladesh. Also, 15 other Litsea species are reported to have cytotoxic activity against various cancer cell lines, making this genus a promising potential source of anticancer compounds. This review provides comprehensive information about the cytotoxicity potential of various species in the genus Litsea along with secondary metabolites responsible, and its potential utility in lung, breast, hepatocellular, ovarian, prostate, colon and cervical cancer therapeutics as a botanical product. The published cytotoxicity data of these plants are mainly based on in vitro studies with very few molecular levels and mechanistic studies conducted. The optimistic results of these 16 species open unexplored vistas of natural product chemistry and the anticancer potential of this genus.

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Pharmacology evaluation of Litsea garciae (Lauraceae)

Cited by 3 publications

References 4 publications

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity

A MINI REVIEW ON THE NUTRITIONAL COMPOSITIONS AND PHARMACOLOGICAL PROPERTIES OF Litsea garciae

The Genus Litsea: A Review of Its Cytotoxic Potential and Phytochemistry

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