Crude Palm Oil (CPO) is one of the typical Indonesian plant that has potential effect as an antioxidant preparation. The purpose of this study was to produce microemulsion with CPO content that had good physical characteristics and also showed antioxidant activity. This research was divided into 3 stages i.e. microemulsion formulation, physical characterization and stability, and antioxidant activity evaluation. The microemulsion was formulated using Phase Titration Method with CPO as oil phase, surfactant tween 80, cosurfactant PEG 400 and aquadest. The treatment in this study was the addition of CPO with various concentration of 5%, 7.5%, and 10% (w/w). The optimum formula was A1 which contained 5% (w/w) CPO. The results showed that this formula had a globule size of 288.87 ± 20.94 nm, zeta potential of -0.36 mV, density of 1.024 ± 6.15x10-5 g/mL, and pH in the range of 4.5-6.5. The microemulsion was stable in storage for 28 days at 25ºC, stable against extreme temperature changes and agitation. The CPO-based microemulsion had IC50 value of 10.5 μg/mL which showed strong antioxidant activity. It can be concluded that CPO-based microemulsion had good physical stability and antioxidant activity for further cosmetic preparation.
Each type of plant has a different response to light, there are some plants that are very sensitive to direct sunlight and too high temperatures and some that are not. This research will take part in producing automatic medicinal plant drying products using the PID method and with the help of a microcontroller as an input and output processor, which will be used for the herbal medicine industry. The supply of load that will be used in this product comes from a combination of direct sunlight energy and solar panels to produce the right drying method and as needed. When the solar energy received by the dryer is excessive, the microcontroller will order the cooler to work and when the heat received is smaller than what has been set, the microcontroller will order the heater to operate. This product is expected to help the community and herbal medicine businesspeople to produce good quality drugs and can be mass produced. From the results of the research obtained is testing the heating control system, indicating that the control system can control the temperature in order to reach the specified target.
Intisari ˗ Industri obat herbal saat ini semakin pesat dengan meningkatnya minat masyarakat terhadap obat herbal di Indonesia. Alat pengering tanaman obat saat ini sudah banyak dikembangkan tetapi masih menggunakan metode konvensional. Metode pengeringan yang tepat sangat berpengaruh pada kandungan bahan aktif yang terdapat pada tanaman. Setiap jenis tanaman mempunyai respon yang berbeda, ada beberapa tanaman yang peka terhadap penyinaran matahari langsung serta suhu yang terlalu tinggi dan ada yang tidak. Pada penelitian sebelumnya, telah dirancang alat pengering tanaman obat yang bekerja secara otomatis dengan bantuan mikrokontroler yang akan digunakan untuk industri obat herbal. Penelitian saat ini akan ambil bagian dalam optimalisasi sistem cerdas dengan menggunakan metode fuzzy logic dan PID sehingga sistem dapat bekerja secara adaptif dan efektif dalam mengatur suhu ruang. Selain itu sistem ini juga dilengkapi dengan Internet of Thing (IoT) pada alat pengering yang memungkinkan untuk dipantau dan dikontrol dari jarak jauh sehingga dapat memudahkan pengguna mengetahui kondisi terkini dari simplisia yang sedang dikeringkan guna meningkatkan kualitas tanaman obat yang sesuai dengan kebutuhan indsutri obat herbal untuk menghasilkan mutu obat yang baik sesuai standar Cara Pembuatan Obat Tradisional yang Baik (CPOTB). Kata kunci: Pengering, Simplisia, CPOTB, Internet of thing, Energi Terbarukan, sistem cerdas.
Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.
The study investigated the suitable land of Ciplukan (Physalisangulata L.), which is a source of medicine ingredient to lower the level of blood sugar. Ciplukan generally grows among wild plants. The objective of this research is to describe the characteristics of the land to grow ciplukan based on the land suitability. The class of land suitability is obtained by matching the physical character and chemistry from botanical garden land and overlaying appropriate maps with the requirements of growing ciplukan with ArcGIS. The class of suitability land acquired in the Botanical Gardens that earned the score of 6 to 8 is an area that does not suitable to cultivate the plants ,with the size 52,189Ha. The score of the lesser appropriate classification was of 9 to 11 with the size of area 180,966Ha. The score of 12 has the size of area 49,111Ha. The score of 12 fulfills 4 parameters. If all the land were suitable, then it would worth 3.9 to 11. The parameters which were not corresponding at all is the value of score was 6 to8. The actual area at the Botanical Garden land was 80 Ha. So, some parts of the land can be used to grow ciplukan.
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