Little has been known about the reduction of uronic acid to the corresponding aldonic acid. A few examples have been presented of the reduction of hexuronic acids, viz. the reduction of D-glucuronic acid or its lactone by TPNH* (1-4) and that of some keturonic acids by DPNH (5-8). On the other hand, it has been established by several workers that the immediate TPN L-Hexonate Dehydrogenase 619 aldehyde reductase proposed recently by Hers (4) or glucuronate reductase (26). A part of this paper was reported previously (25, 27). METHODS AND MATERIALS Materials•\D-Glucurono-r-lactone, sodium D-glu curonate, ethyl D-glucuronate, and D-glucuronamide were obtained from the Chugai Pharmaceutical Com pany. D-Galacturonate was purchased from the Nutritional Biochemicals Corporation, D-mannurono-ƒÁ-lactone was provided through the courtesy of Dr .
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