These results suggested that the duration of exposure to both CPT-11 and SN-38 of the intestinal epithelium and CPT-11 plasma Cmax are closely related to the incidence and severity of CPT-11-induced delayed-onset diarrhea in rats.
Abstract. Tubulointerstitial fibrosis is a common feature of many progressive renal diseases and is a main determinant that leads to an irreversible loss of renal function. In chronic cyclosporin A nephrotoxicity, we previously reported that inflammatory responses such as macrophage infiltration preceded interstitial fibrosis. This inflammation was accompanied by an elevation in renal nuclear factor κB (NF-κB) activity. Similar findings were obtained in chronic tacrolimus nephrotoxicity and obstructive nephropathy. Inhibition of NF-κB markedly attenuated renal inflammation and interstitial fibrosis in these models. Furthermore, administration of oral adsorbent (Kremezin ® ) significantly attenuated the increase in renal NF-κB activity and concomitantly reduced interstitial inflammation and renal fibrosis in chronic renal failure rats. Elimination of indoxyl sulfate by this adsorbent is likely involved in this mechanism since it is known that indoxyl sulfate activates NF-κB in renal tubular cells. It is suggested that strategy aiming at NF-κB inhibition is important to prevent the progression of renal fibrosis.
An overview of the Inter-university Upper atmosphere Global Observation NETwork (IUGONET) project is presented with a brief description of the products to be developed. This is a Japanese inter-university research program to build the metadata database for ground-based observations of the upper atmosphere. The project also develops the software to analyze the observational data provided by various universities/institutes. These products will be of great help to researchers in efficiently finding, obtaining, and utilizing various data dispersed across the universities/institutes. This is expected to contribute significantly to the promotion of interdisciplinary research, leading to more a comprehensive understanding of the upper atmosphere.
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