Modified irinotecan hydrochloride (CPT-11) administration schedule improves induction of delayed-onset diarrhea in rats

Abstract

These results suggested that the duration of exposure to both CPT-11 and SN-38 of the intestinal epithelium and CPT-11 plasma Cmax are closely related to the incidence and severity of CPT-11-induced delayed-onset diarrhea in rats.

Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation

“…The intestinal injury following irinotecan administration is associated with inXammatory inWltrate within the gut wall [7,19]. In the present study, neutrophil inWltration into intestinal lesion was indirectly evaluated by the myeloperoxidase activity assay.…”

“…The severity of the diarrhea was scored as described by Kurita et al [19] as follows: 0-normal, normal stool or absent; 1-slight, slightly wet and soft stool; 2-moderate, wet and unformed stool with moderate perianal staining of the coat; and 3-severe, watery stool with severe perianal staining of the coat.…”

Alteration of the Pharmacokinetics of COL-3, a Matrix Metalloproteinase Inhibitor, Due to Acute Gastrointestinal Toxicity of Doxorubicin

“…The severity of acute diarrhea in all experimental rats was assessed according to the rating scale as described previously (20,21): 0 (normal), normal stool or absent; 1 (slight), slightly wet and soft stool; 2 (moderate), wet and unformed stool with moderate perianal staining of the coat; and 3 (severe), watery stool with severe perianal staining of the coat. Scoring of acute diarrhea was conducted at 4 and 24 h after dosing.…”

Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate

“…MTX and diaminobenzidine were purchased from Wako Pure Chemical Industries (Osaka, Japan (19,20). After the consecutive i.p.…”