1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical évolution and EEG modifications. 2. ';ialoperidol plasma levels were determlned by radioiïïim'onoassay. Clinical status vas assessed weekly and computerized EEG were performed daily from day 3 to 7 after halo peridol decanoate injection. 3. The olasraa leveldose relationshlp during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the olasma level atteins its highest value within 3 to 10 days and decreases along a logarithmic curve. An in verse relationshlp with B.P.R.S.scores is found in many patients. EEG changes are re lated to clinical status rather than to plasma levels. 4. The results obtained by thèse three methods are proposed as criteria for the assessment of~the reinjection time.
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