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SUMMARYBackground: Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglobin content. Aim: We questioned how oxygen supplementation would influence the hepatic microsomal function as assessed by the 13 C-methacetin breath test in patients with cirrhosis of different severity and different degrees of anaemia. Methods: 13 C/ 12 C ratios in exhaled breath assessed by non-dispersive infrared spectrometry were studied in 34

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