Hepatic arterial blood flow velocities: assessment by transcutaneous and intravascular Doppler sonography

Hübner, Georg; Steudel, Norbert; Kleber, Gerhard; Behrmann, C.; Lotterer, E.

doi:10.1016/s0168-8278(00)80093-8

Cited by 30 publications

(24 citation statements)

References 18 publications

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“…[14][15][16][17]21,22 Normally, there is scant collagen in perisinusoidal space and collagens are the most abundant protein in this matrix. Higher degrees of fatty liver is seen with high BMI adolescents.…”

Section: Discussionmentioning

confidence: 99%

Hepatic artery resistance in children with obesity and fatty liver

Hızlı

Koçyi̇ği̇t²,

Arslan

et al. 2010

Indian J Pediatr

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Section: Discussionmentioning

confidence: 99%

Hepatic artery resistance in children with obesity and fatty liver

Hızlı

Koçyi̇ği̇t²,

Arslan

et al. 2010

Indian J Pediatr

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“…In an effort to approximate a representative flow waveform in the hepatic arterial system, the blood pulse was estimated based on the published figures of flow waveforms in the right hepatic artery from Taylor et al 33 and Hu¨bner et al, 14 where the magnitudes were adjusted to match (i) antegrade (forward) flow in the diastolic region of the pulse 27 ; (ii) a weighted average mean flow rate; and (iii) maximum flow-rate value calculated from multiple ultrasound and anatomic studies in the right hepatic artery. Table 3 lists the data from the different studies, the experimental method used to obtain each measurement, and the weighted averages of each compiled data set.…”

Section: Boundary Conditionsmentioning

confidence: 99%

Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

et al. 2010

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Combating liver tumors via yttrium-90 ((90)Y) radioembolization is a viable treatment option of nonresectable liver tumors. Employing clinical (90)Y microparticles (i.e., SIR-Spheres and TheraSpheres) in a computational model of a representative hepatic artery system, laminar transient 3D particle-hemodynamics were simulated. Specifically, optimal particle release positions in the right hepatic (parent) artery as well as the best temporal release window were determined for the microspheres to exit specific outlet daughter vessels, potentially connected to liver tumors. The results illustrate the influence of a curved geometry on the velocity field and the particle trajectory dependence on the spatial and temporal particle injection conditions. The differing physical particle characteristics of the SIR-Spheres and the TheraSpheres had a subtle impact on particle trajectories in the decelerating portion of the arterial pulse, i.e., when the inertial forces on the particles are weaker. Conversely, particle characteristics and inelastic wall collisions had little effect on particles released during the accelerating phase of the arterial pulse, i.e., both types of microspheres followed organized paths to predetermined outlets. Such results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels (e.g., those connected to tumors) under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology.

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“…1a and 1b). Specifically, vessel diameters, curvatures, and branching patterns, as well as blood flow velocities/pressures and microsphere characteristics (i.e., diameter and specific gravity), were selected based on representative biological data (3,(10)(11)(12)(13). SolidWorks (Dassault Systems, SolidWorks Corp, Santa Monica, CA) 3-D computer-aided design (CAD) software (1) was used to create the vessel geometries, consisting of a curved right hepatic artery with one branch vessel to the normal liver and a triple-branch daughter vessel leading selectively to a tumor.…”

Section: Modeling Proceduresmentioning

confidence: 99%