Computer Modeling of Yttrium-90–Microsphere Transport in the Hepatic Arterial Tree to Improve Clinical Outcomes

Kennedy, Andrew S.; Kleinstreuer, Clement; Basciano, Christopher A.; Dezarn, William A.

doi:10.1016/j.ijrobp.2009.06.069

Cited by 79 publications

(78 citation statements)

References 26 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 60%-40% microsphere spreading was found by Kennedy et al (11) in the steady-state dynamics for a particular bifurcation geometry. Basciano et al (13) showed that just following the catheter tip the microsphere spreading can still be more asymmetric between the daughter vessels, depending on the injection time frame versus the blood motion phase.…”

Section: Posttherapy 90 Y Tof Petmentioning

confidence: 64%

“…By computer modeling of the steady-state flow, Kennedy et al (11) derived that in the arterial branch geometry shown in Figure 2 (left), microsphere spreading doesn't follow that of the blood, and typically 20%, 30%, 30%, and 20% of the microspheres go through daughter vessels 1, 2, 3, and 4, respectively.…”

Section: Microsphere Transport Modelmentioning

confidence: 99%

“…Four 120-Gy whole-liver dose simulations were performed: 2 simulations with periodic microsphere distribution, assuming 1, or 6, glass microspheres trapped in every, or only in 1 of 6, portal tracts, and 2 random simulations using the microsphere transport model with P 5 0.5 (i.e., equirelative-spreading probability between 2 daughter vessels) and with P 5 0.4 as derived by Kennedy et al (11).…”

Section: Fixed-length Artery Treementioning

confidence: 99%

“…For each random simulation, 100,000 realizations were performed in a liver subvolume of 16 · 16 · 16 mm, which contained about 2 11 lobules. All the portal tracts of this subvolume were thus assumed to share a common arterial path of 21 -11 5 10 nodes length.…”

Section: Fixed-length Artery Treementioning

confidence: 99%

See 3 more Smart Citations

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

Walrand

Hesse

Chiesa³

et al. 2013

J Nucl Med

View full text Add to dashboard Cite

90 Y resin and glass microsphere liver radioembolizations delivering lobar doses of 70 and 120 Gy, respectively, display hepatic toxicity similar to 40-Gy fractionated external-beam radiotherapy. We investigated how the lower number of glass microspheres could induce a sufficiently nonuniform dose distribution explaining this paradox. Methods: Microscale dosimetry was assessed in the realistic liver model developed by Gulec et al. but using the Russell's dose deposition kernel. A lattice of hexagonal prisms represented the hepatic lobules. Two hepatic arterial tree models-that is, a fixed-length and a variable-branches length-were used for the microsphere transport. Equal or asymmetric microsphere relative-spreading probability between 2 daughter vessels was assumed. Several 120-Gy liver simulations were performed: periodic simulations, where 1 or 6 glass microspheres were trapped in all and in only 1 of 6 portal tracts, respectively, and random simulations, where glass microsphere trapping assumed an equal probability for all the portal tracts or a variable probability depending on the successions of artery connections leading to the portal tract, both for the 2 arterial tree models. Results: For the 2 uniform simulations, all hepatic structures received at least 100 Gy. The fast decrease of the 90 Y kernel as the inverse of the square of the distance r is counterbalanced by the number of contributing lobules containing microspheres that increases as r 2 . The random simulation with equal-spreading probability gave for the less irradiated tissue a lobule dose distribution centered around 103 Gy (full width at half maximum, 20 Gy). The distribution became significantly asymmetric with the 60%-40% relative-spreading probability, with a shift of the maximum from 103 down to 50 Gy, and about 17% of the lobules got a dose lower than 40 Gy to their different structures. Conclusion: The large nonuniform trapping produced by the microsphere transport in the arterial tree jointly with the low number of injected glass microspheres begins to explain their lower hepatic toxicity per Gray. In addition, the nonuniform trapping supports the fact that the granular aspect of 90 Y PET imaging observed in patients could represent some reality and not only statistical noise.

show abstract

Section: Posttherapy 90 Y Tof Petmentioning

confidence: 64%

Section: Microsphere Transport Modelmentioning

confidence: 99%

Section: Fixed-length Artery Treementioning

confidence: 99%

Section: Fixed-length Artery Treementioning

confidence: 99%

See 2 more Smart Citations

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

Walrand

Hesse

Chiesa³

et al. 2013

J Nucl Med

View full text Add to dashboard Cite

show abstract

“…A 5-10 mm difference in catheter position between tip and artery opening has been shown to have a major impact on microsphere flow distribution [58,77]. Fluid dynamic models of MS transport in a hepatic arterial system highlight the influence of the injection time interval, specific daughter vessel targeting, microsphere injection velocity, and vessel morphology [78,79].…”

Section: Using 99m Tc-maa As a 90 Y Ms Surrogatementioning

confidence: 99%

A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy

Doherty¹

2015

J Diagn Imaging Ther

View full text Add to dashboard Cite

Yttrium-90 radioembolization ( 90 Y-RE) is a well-established therapy for the treatment of hepatocellular carcinoma (HCC) and also of metastatic liver deposits from other malignancies. Nuclear Medicine and Cath Lab diagnostic imaging takes a pivotal role in the success of the treatment, and in order to fully exploit the efficacy of the technique and provide reliable quantitative dosimetry that are related to clinical endpoints in the era of personalized medicine, technical challenges in imaging need to be overcome. In this paper, the extensive literature of current 90 Y-RE techniques and challenges facing it in terms of quantification and dosimetry are reviewed, with a focus on the current generation of 3D dosimetry techniques. Finally, new emerging techniques are reviewed which seek to overcome these challenges, such as highresolution imaging, novel surgical procedures and the use of other radiopharmaceuticals for therapy and pre-therapeutic planning.

show abstract

Microfluidic Devices for Nanodrug Delivery

Kleinstreuer

2010

Microfluidic Devices in Nanotechnology

View full text Add to dashboard Cite

Computer Modeling of Yttrium-90–Microsphere Transport in the Hepatic Arterial Tree to Improve Clinical Outcomes

Cited by 79 publications

References 26 publications

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy

Microfluidic Devices for Nanodrug Delivery

Contact Info

Product

Resources

About

Computer Modeling of Yttrium-90–Microsphere Transport in the Hepatic Arterial Tree to Improve Clinical Outcomes

Cited by 79 publications

References 26 publications

The Low Hepatic Toxicity per Gray of 90Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

The Low Hepatic Toxicity per Gray of 90Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90Y microsphere therapy

Microfluidic Devices for Nanodrug Delivery

Contact Info

Product

Resources

About

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging

The Low Hepatic Toxicity per Gray of ⁹⁰Y Glass Microspheres Is Linked to Their Transport in the Arterial Tree Favoring a Nonuniform Trapping as Observed in Posttherapy PET Imaging