Oxygen supplementation improves methacetin clearance in patients with cirrhesis-relation to liver function

Functional significance of hepatic arterial flow reserve in patients with cirrhosis

“…1 Indeed, previous studies in animals and humans suggest improvement of hepatic function during oxygen supplementation. [2][3][4] As shown in normal animals 5 as well as in those with cirrhosis, 6 the reduction in portal venous blood flow may be compensated by increased hepatic arterial flow (i.e., the hepatic arterial buffer response). Augmentation in hepatic arterial flow may improve hepatic oxygen supply and facilitate clearance of substrates metabolized via cytochrome P450 in the presence of molecular oxygen.…”