Sensitivity encoding (SENSE) and partial Fourier techniques have been shown to reduce the acquisition time and provide high diagnostic quality images. However, for time-resolved acquisitions there is a need for both high temporal and spatial resolution. View sharing can be used to provide an increased frame rate but at the cost of acquiring spatial frequencies over a duration longer than a frame time. In this work we hypothesize that a CArtesian Projection Reconstruction-like (CAPR) technique in combination with 2D SENSE, partial Fourier, and view sharing can provide 1-2 mm isotropic resolution with sufficient temporal resolution to distinguish intracranial arterial and venous phases of contrast passage in whole-brain angiography. In doing so, the parameter of "temporal footprint" is introduced as a descriptor for characterizing and comparing time-resolved view-shared pulse sequences. It is further hypothesized that short temporal footprint sequences have higher temporal fidelity than similar sequences with longer temporal footprints. The tradeoff of temporal footprint and temporal acceleration is presented and characterized in numerical simulations. Since its initial description over a decade ago (1), 3D contrast-enhanced MR angiography (CE-MRA) has become a widely used technique (2,3). Over the interim the method has undergone a number of technical advances allowing improved spatial and temporal resolution, including reduction of TR times, altered view orders to allow extended acquisition times (4), means for timing the acquisition to the arterial phase (5-7), development of stack of stars and 3D projection reconstruction (PR) techniques with application to MRA (8,9), and use of partial Fourier acquisition (10). More recently, parallel imaging methods (11-14) have been applied to 3D CE-MRA (15-23). A number of these methods can be applied synergistically.Along with improvements in spatial resolution, there has been progress in the generation of time-resolved 3D CE-MRA datasets. This can be done by simply recycling an unaccelerated 3D pulse sequence (24,25) or by using view sharing to provide an image update rate shorter than the intrinsic acquisition time (26 -28). Other versions of these methods have been developed (29 -36), including the use of such techniques as projection reconstruction (37) and spiral acquisition (38). Also, a method based on viewshared PR and slice encoding combined with nonlinear processing has been developed for time-resolved imaging (39). A number of these methods for time-resolved MRA have been integrated with the above-mentioned parallel imaging for either improved temporal or spatial resolution. Applying parallel imaging along one dimension has been used to provide acceleration factors as high as 3 to 4 for time-resolved sequences (11,16,18,32,40 -42). However, it has been shown for sensitivity encoding (SENSE) that for a given acceleration factor, 2D acceleration has markedly less signal-to-noise ratio (SNR) penalty than 1D (13). To our knowledge the first applications of 2D paral...

Magnetic resonance (MR) angiography has undergone significant development over the past decade. It has gone from being a novelty application of MR with limited clinical use to replacing catheter angiography in some clinical applications. One of the principal limitations inherent to all MR angiographic techniques is that they remain signal limited when pushed to the limits of higher resolution and short acquisition time. Developments in magnetic gradient hardware, coil design, and pulse sequences now are well optimized for MR angiography obtained at 1.5-T main magnetic field (B-field) strength, with acquisition times and imaging matrix size near their optimal limits, respectively. Recently, the United States Food and Drug Administration (FDA) approved use of clinical magnetic resonance imaging with main magnetic field strengths of up to 4 T. Before FDA approval, use of MR with magnetic field strengths much greater than 1.5 T was essentially reserved for investigational or research applications. The main advantage of high B-field imaging is a significant improvement in the signal-to-noise ratio (SNR), which increases in an approximately linear fashion with field strength in the range of 1.5 to 3.0 T. This increased SNR is directly available when performing MR angiographic acquisitions at higher magnetic field strengths, allowing for better resolution and conspicuity of vessels with similar acquisition times. Little has been reported on the benefits of performing MR angiography at magnetic field strengths >1.5 T. The purpose of this article is to summarize our current experience with intracranial and cervical MR angiographic techniques at 3.0 T.

A non-Jewish patient is described who had adult polyglucosan body disease (APBD) and glycogen branching enzyme (GBE) deficiency without GBE mutation. A heterozygous polymorphism (Val160Ile) was found, and also discovered in 1 of 50 normal individuals. Magnetic resonance imaging demonstrated increased T2 signal in the midbrain, medullary olives, dentate nuclei, cerebellar peduncles, and internal and external capsules, with vermian atrophy. Both muscle and nerve biopsy revealed perivascular inflammatory infiltrates. These findings expand the clinical and genetic spectrum of APBD. Factors other than mutation of the expressed GBE gene may cause enzyme deficiency and varied expression and development of APBD.

CAPR is a SENSE-type parallel 3DFT acquisition paradigm for 4D contrast-enhanced magnetic resonance angiography (CE-MRA) that has been demonstrated capable of providing high spatial and temporal resolution, diagnostic-quality images at very high acceleration rates. However, CAPR images are typically reconstructed online using Tikhonov regularization and partial Fourier methods, which are prone to exhibit noise amplification and undersampling artifacts when operating at very high acceleration rates. In this work, a sparsity-driven offline reconstruction framework for CAPR is developed and demonstrated to consistently provide improvements over the currently-employed reconstruction strategy against these ill-effects. Moreover, the proposed reconstruction strategy requires no changes to the existing CAPR acquisition protocol, and an efficient numerical optimization and hardware system are described that allow for a 256×160×80 volume CE-MRA volume to be reconstructed from an 8-channel data set in less than two minutes.

This case report demonstrates the ultrasound appearance of synovial osteochondromatosis of the shoulder, along with plain film radiographic, computed tomographic, and pathologic correlation. Because of recent renewed interest in the use of ultrasonography in the evaluation of musculoskeletal disease, such as rotator cuff arthropathy or suspected intra-articular loose body, opportunities to diagnose synovial osteochondromatosis with this modality have become more frequent.