Data on the natural course of gastrooesophageal reflux disease are sparse. One hundred and sixty six patients with typical reflux symptoms (heartburn and/or acid regurgitation) and pathologic pH monitoring (reflux time >8*2% upright and/or >3*0% supine) were studied.The patients were followed up by questionnaire and interview for a mean of 41 (seven to 86) months after diagnosis of reflux disease.
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