Optimal thresholds, sensitivity, and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease

Schindlbeck, Norbert E.; Heinrich, Christine; König, August; Dendorfer, Andreas; Pace, F.; Müller-Lissner, S

doi:10.1016/0016-5085(87)90318-0

Cited by 220 publications

(116 citation statements)

References 16 publications

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“…Gastroesophageal reflux (GER) is common in patients with asthma, with an estimated prevalence of 34-80% (24,25), vs. 5-10% in the general population (26). This large variation in GER prevalence reflects substantial differences in the standards applied for establishing the diagnosis of both asthma and GER and the frequency of silent GER (27).…”

Section: Gastroesophageal Refluxmentioning

confidence: 99%

Difficult asthma

Garcia

and

Humbert

2003

Allergy

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Section: Gastroesophageal Refluxmentioning

confidence: 99%

Difficult asthma

Garcia

and

Humbert

2003

Allergy

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“…the fraction of time at pH < 4. [18][19][20] Indeed, the percentage acid reflux time is currently considered to be the most useful parameter for the analysis and interpretation of 24-h oesophageal pH studies. 21 A knowledge of the role, if any, of supine nocturnal oesophageal acid exposure in the pathogenesis of oesophageal mucosal lesions may have practical implications.…”

Section: Introductionmentioning

confidence: 99%

Different patterns of oesophageal acid exposure distinguish complicated reflux disease from either erosive reflux oesophagitis or non‐erosive reflux disease

Frazzoni

Micheli

Savarino

2003

Aliment Pharmacol Ther

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SummaryBackground : The reason why less than one‐half of patients with gastro‐oesophageal reflux disease develop complicated reflux disease (ulcerative oesophagitis, oesophageal strictures and Barrett's oesophagus) and erosive reflux oesophagitis is not fully understood. Supine nocturnal oesophageal acid reflux is considered to be critically involved in this phenomenon, but reliable data are lacking.Aim : To clarify whether high levels of supine nocturnal oesophageal acid exposure are associated with complicated reflux disease.Methods : Ambulatory 24‐h oesophageal pH monitoring was performed in 220 patients with gastro‐oesophageal reflux disease (56 with complicated reflux disease, 76 with erosive reflux oesophagitis and 88 with non‐erosive reflux disease). The total, supine nocturnal and upright diurnal percentage acid reflux times were calculated.Results : The total percentage acid reflux time was significantly greater in complicated reflux disease than in either erosive reflux oesophagitis (P = 0.024) or non‐erosive reflux disease (P = 0.000). These differences were entirely due to a greater supine nocturnal percentage acid reflux time (P = 0.038 and P = 0.000, respectively), whereas no difference was observed in the upright diurnal percentage acid reflux time.Conclusions : Complicated reflux disease is characterized by high levels of supine nocturnal percentage acid reflux time. Prospective studies would be appropriate to clarify whether the normalization of this parameter is relevant to the effective management of this subset of patients with gastro‐oesophageal reflux disease.

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“…Practically, all the children who cooperated in the UGIS also did it with the IEUS (94.74%). Among the 22 children who were noncooperative A B nal region of the esophagus for 24-hour continuous recording of the ph values in this region (17) . Because of this method characteristics, it is considered as an invasive study.…”

Section: Resultsmentioning

confidence: 99%

“…Intermittent observation of the stomach fundus filled with barium is performed with radioscopy for detecting the contrast medium reflux from the stomach backwards up to the esophagus (10) . Currently, the comparative study of IEUS and UGIS has demonstrated that IEUS presents a higher sensitivity in the diagnosis of GER (9,17) and in the evaluation of the intraabdominal esophagus, with a reduction of the exposure to ionizing radiation for these patients (11,18) . However, the determination of reflux degree as well as the evaluation of the intrathoracic esophagus cannot be performed with this method (18,19) .…”

Section: Resultsmentioning

confidence: 99%

Refluxo gastroesofágico: estudo comparativo da receptividade e sensibilidade entre seriografia e ultrassonografia

et al. 2009

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OBJECTIVE: Comparative study of receptiveness (cooperation) and sensitivity of upper gastrointestinal series and intraabdominal esophagus ultrasonography in patients with suspicion of gastroesophageal reflux. MATERIALS AND METHODS: The present study included 42 pediatric patients (26 male, with mean age of 33.64 ± 34.33 months, and 16 female, with mean age of 31.02 ± 35.56 months) with suspicion of gastroesophageal reflux, who were initially submitted to upper gastrointestinal series and subsequently to intraabdominal esophagus ultrasonography. RESULTS: The statistical comparative analysis covering sexes and ages suggests no evidence of association with cooperation, both for the upper gastrointestinal series and the intraabdominal esophagus ultrasonography. However, in the classification of the patients' cooperation, the technique of upper gastrointestinal series presented less than 50% of cooperation, while 80.49% of patients cooperated in the intraabdominal esophagus ultrasonography examinations. As regards the methods sensitivity for the diagnosis of gastroesophageal reflux, the technique of intraabdominal esophagus ultrasonography was significantly superior (85.7%) to the upper gastrointestinal series (47.6%). CONCLUSION: The present study suggests that an intraabdominal esophagus ultrasonography should be performed even if gastroesophageal reflux even if it is not detected at the upper gastrointestinal series. Keywords: Gastroesophageal reflux; Intraabdominal esophagus; Ultrasonography; Contrast-enhanced study.OBJETIVO: Estudo comparativo da receptividade (colaboração) e sensibilidade da seriografia do esôfago, estômago e duodeno em relação à ultrassonografia do esôfago intra-abdominal em pacientes com suspeita de refluxo gastroesofágico. MATERIAIS E MÉTODOS: Foram incluídos no estudo 42 pacientes pediátricos (26 masculinos, com idade média de 33,64 ± 34,33 meses, e 16 femininos, com idade média de 31,02 ± 35,56 meses) com suspeita de refluxo gastroesofágico, os quais foram submetidos, inicialmente, a seriografia do esôfago, estômago e duodeno, e posteriormente, a ultrassonografia do esôfago intra-abdominal. RESUL-TADOS: A análise estatística comparativa entre os sexos e as idades sugere não haver evidência de associação com a colaboração, tanto para a seriografia do esôfago, estômago e duodeno como para a ultrassonografia do esôfago intra-abdominal. Entretanto, na classificação quanto ao tipo de colaboração, a técnica de seriografia do esôfago, estômago e duodeno apresentou menos de 50% de colaboração, enquanto 80,49% dos pacientes colaboraram com a ultrassonografia do esôfago intra-abdominal. Quanto à sensibilidade do diagnóstico de refluxo gastroesofágico, a técnica de ultrassonografia do esôfago intra-abdominal (85,7%) foi significativamente superior à de seriografia do esôfago, estômago e duodeno (47,6%). CONCLUSÃO: O presente estudo sugere que se proceda a ultrassonografia do esôfago intra-abdominal, mesmo na ausência de refluxo gastroesofágico na seriografia do esôfago, estômago e duodeno. Unitermos:...

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Optimal thresholds, sensitivity, and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease

Cited by 220 publications

References 16 publications

Difficult asthma

Difficult asthma

Different patterns of oesophageal acid exposure distinguish complicated reflux disease from either erosive reflux oesophagitis or non‐erosive reflux disease

Refluxo gastroesofágico: estudo comparativo da receptividade e sensibilidade entre seriografia e ultrassonografia

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