The effect of Tinospora crispa stem aqueous extract in hypercholesterolemic-induced rabbit was investigated. Results from this study showed that the plasma lipid profiles improved with T. crispa supplementation as indicated by reduced total cholesterol, triglycerides, low density lipoprotein levels and increased high density lipoprotein level significantly in T. crispatreated groups relative to the hypercholesterolemic control group. T. crispa extract was also found to have strong antioxidative properties as evident from low plasma malondialdehyde level in all T. crispa-treated groups when compared with the control. The value of atherosclerotic index was decreased in T. crispa-treated groups in comparison with the hypercholesterolemic control group. At the same time, T. crispa markedly reduced the atherosclerotic lesion formation after 10 weeks of treatment in hypercholesterolemic rabbits. Hence, T. crispa can be incorporated as part of the therapeutic regiment together with other hypocholesterolemic drugs in the prevention of atherosclerosis.3 Corresponding
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