An Aqueous Extract of Tinospora Crispa Possesses Antioxidative Properties and Reduces Atherosclerosis in Hypercholesterolemic-Induced Rabbits

Amom, Zulkhairi; Azman, Khairunnuur Fairuz; Ismail, Nor Amalina; Shah, Zamree Md; Arshad, Mohd Shahidan Mohamad

doi:10.1111/j.1745-4514.2010.00436.x

Cited by 10 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amom et al ( 2011 ) discovered that the aqueous extract from T. crispa stem administered to hypercholesterolemic rabbits delayed the development of atherosclerosis by suppressing the levels of total cholesterol, triglycerides and low density lipoproteins. In contrast, the level of high density lipoproteins was found to be significantly increased.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

2016

View full text Add to dashboard Cite

Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae), found in the rainforests or mixed deciduous forests in Asia and Africa, is used in traditional medicines to treat numerous health conditions. This review summarizes the up-to-date reports about the ethnobotany, phytochemistry, pharmacological activities, toxicology, and clinical trials of the plant. It also provides critical assessment about the present knowledge of the plant which could contribute toward improving its prospect as a source of lead molecules for drug discovery. The plant has been used traditionally in the treatment of jaundice, rheumatism, urinary disorders, fever, malaria, diabetes, internal inflammation, fracture, scabies, hypertension, reducing thirst, increasing appetite, cooling down the body temperature, and maintaining good health. Phytochemical analyses of T. crispa revealed the presence of alkaloids, flavonoids, and flavone glycosides, triterpenes, diterpenes and diterpene glycosides, cis clerodane-type furanoditerpenoids, lactones, sterols, lignans, and nucleosides. Studies showed that the crude extracts and isolated compounds of T. crispa possessed a broad range of pharmacological activities such as anti-inflammatory, antioxidant, immunomodulatory, cytotoxic, antimalarial, cardioprotective, and anti-diabetic activities. Most pharmacological studies were based on crude extracts of the plant and the bioactive compounds responsible for the bioactivities have not been well identified. Further investigations are required to transform the experience-based claims on the use of T. crispa in traditional medicine practices into evidence-based information. The plant extract used in pharmacological and biological studies should be qualitatively and quantitatively analyzed based on its biomarkers. There should be detail in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds and more elaborate toxicity study to ensure safety of the plant for human use. More clinical trials are encouraged to be carried out if there are sufficient preclinical and safety data.

show abstract

Section: Pharmacological Propertiesmentioning

confidence: 99%

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

2016

View full text Add to dashboard Cite

show abstract

“…However, the underlying mechanism of action for these effects is still unclear. The presence of antioxidants like flavonoids and phenolics in T. crispa may help to reduce inflammation in the body due to their cytoprotective and anti-inflammatory actions [9, 11–13]. Kidney and spleen showed no significant changes in relative organ weight (ROW) in the HFDTC group (Table 7).…”

Section: Discussionmentioning

confidence: 99%

“…There were no other specific mechanisms of action of T. crispa' s antioxidants properties in reducing the body weight on treated rats [14] but common alkaloid; berberine compound was suggested as an antiobesity agent due to the activity of AMP-activated protein kinase (AMPK) in the peripheral tissues [13]. Berberine was proposed to elevate the fatty acid oxidation through activation of AMPK in muscle cells and thus improving lipid metabolism in the body which was frequently related to hyperlipidemia and fatty liver in obese patients [5].…”

Section: Discussionmentioning

confidence: 99%

Tinospora crispaAmeliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats

Abu

Samat

Kamarapani

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated with T. crispa (HFDTC), and the high fat diet treated with orlistat (HFDO). After sixteen weeks of treatment, blood and organs were harvested for analyses. Results showed that T. crispa significantly (p < 0.05) reduced the body weight (41.14 ± 1.40%), adiposity index serum levels (4.910 ± 0.80%), aspartate aminotransferase (AST: 161 ± 4.71 U/L), alanine aminotransferase (ALT: 100.95 ± 3.10 U/L), total cholesterol (TC: 18.55 ± 0.26 mmol/L), triglycerides (TG: 3.70 ± 0.11 mmol/L), blood glucose (8.50 ± 0.30 mmo/L), resistin (0.74 ± 0.20 ng/mL), and leptin (17.428 ± 1.50 ng/mL) hormones in HFDTC group. The insulin (1.65 ± 0.07 pg/mL) and C-peptide (136.48 pmol/L) hormones were slightly decreased but within normal range. The histological results showed unharmed and intact liver tissues in HFDTC group. As a conclusion, T. crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet.

show abstract

“…Atherosclerosis, the most common heart disease, is an abnormal accumulation, oxidation, and modification of lipids that mostly causes the chronic inflammation in walls of arteries, vessel stenosis, and lumen obstruction and reduces the blood flow to the myocardial muscle (Amom, Azman, Ismail, Shah, & Arshad, ). Many factors can contribute to the development of atherosclerosis such as hypercholesterolemia, diabetes, smoking, obesity, hypertension, and inactivity (Insull, ).…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats

Parvin

Yaghmaei

Noureddini

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol for 40 days; and experimental groups were separately treated by atorvastatin, quercetin, and hydroalcoholic extract for 4 weeks. After treatment procedure, some serum factors such as low‐density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA), and reactive oxygen species (ROS) were evaluated. Serum levels of LDL, TC, MDA, and ROS were significantly lower in experimental groups than sham group (p < .01). There was a significant decrease in serum MDA levels of these two groups in comparison with the atorvastatin‐treated group (p < .05). Blood pressure parameters were decreased in treated with quercetin and hydroalcoholic extract in comparison with the sham group (p < .05). Quercetin and hydroalcoholic extract similar to atorvastatin could decrease serum lipids [except high‐density lipoprotein (HDL)], oxidative stress factors, aorta contraction, weight gain, and blood pressure. These reagents improved the vascular structure and prevented the plaque formation.

show abstract

An Aqueous Extract of Tinospora Crispa Possesses Antioxidative Properties and Reduces Atherosclerosis in Hypercholesterolemic-Induced Rabbits

Cited by 10 publications

References 32 publications

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

Tinospora crispaAmeliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats

Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats

Contact Info

Product

Resources

About