In the last two decades, nanotechnology has flourished due to its vast number of applications in many fields such as drug delivery, oil and gas, and thermal applications, like cooling and air-conditioning. This study focuses on the applications of nanoparticles/nanofluids in the Enhanced Oil Recovery (EOR) process to increase oil recovery efficiency. To understand the nanoparticle-assisted EOR process, the first step is to understand the flow characteristics of nanoparticles in porous media, including entrapment and release in the pores and the behavior of nanoparticles under high temperatures, pressures, and salinity levels and in the presence of external electric and magnetic fields. Also, the process looks at the roles of various pore distributions during their application as EOR agents. The experimental approaches are not only time consuming, but they are also cumbersome and expensive. Hence, the mathematical models could help to facilitate the understanding of the transport and interaction of nanofluids in a reservoir and how such processes can be optimized to get maximum oil recovery and, in turn, reduce the production cost. This paper reviews and critically analyzes the latest developments in mathematical modeling and simulation techniques that have been reported for nanofluid-assisted EOR. One section is dedicated to discussing the challenges ahead, as well as the research gaps in the modeling approach to help the readers to also contribute to further enlightening the modeling nanofluid-assisted EOR process.
Dendrophthoe pentandra (DP) is a semi-parasitic plant. Previous studies showed that this plant possessed diverse medicinal properties. The present study was carried out to determine antiproliferative activity of various DP crude extracts. Extracts of petroleum ether, diethyl ether, chloroform, ethyl acetate and methanol, have been evaluated through IC50 value, which defined by the concentration of drug that is required for the inhibition of 50% of cell population in vitro. The determination of percentage cell viability was conducted by using MTT assay. The screening assay involved the use of malignant cell line MCF-7 (breast cancer cell) whereas the normal cell line was L929 (connective cell). The control drug used was tamoxifen. The ethyl acetate and methanol extracts were found to be more effective against MCF-7 cancer cell lines compared to the others. All extracts showed no remarkable effect against normal cell L929 with IC50 values more than 100 µg/mL. In contrast to tamoxifen, all extracts showed less cytotoxicity effect towards normal cells. The data obtained from this study provide notable preliminary information on the cytotoxic/antiproliferative effect of different DP extracts and further study should be carried out to isolate the active compound of the most potential DP extracts.
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