Background Polypharmacy has become a global public health concern particularly in the elderly population. The elderly population is the most susceptible to the negative effects of polypharmacy due to their altered pharmacokinetics and decreased drug clearance. Therefore, polypharmacy can lead to poor health status and higher rates of morbidity and mortality. Objective The objective of this study was to determine the prevalence of polypharmacy (� 5 drugs) and its association with non-communicable diseases (NCDs) in elderly (�65 years) Qatari patients attending Primary Healthcare (PHC) centers in Qatar. Methods A retrospective cross-sectional analysis was conducted using the Electronic Medical Record (EMR) database of all PHC centers in Qatar for six months (April-September 2017). Results Out of 5639 patients screened, 75.5% (95% CI: 74.3-76.6) were exposed to polypharmacy. Females were 1.18 times more likely to have polypharmacy compared to males (95% CI: 1.03-1.34). The multivariate analysis identified having hypertension (

The following information is missing from the Funding statement: Open Access funding is provided by the Qatar National Library.