Introduction: This research work was carried out to determine chemical components of Persea americana seed. Persea americana (avocado) is widely grown fruit in parts of South East, Nigeria, where it is used as a medicinal plant in the treatment of several ailments by alternative medical practitioners. Materials and Methods: The chemical components of Persea americana seed includes the proximate and minor components. The fleshy part of the fruit was removed to obtain the seed. The dried seeds were ground to powder and dried to constant weight. Results: The seed is high in carbohydrate (49.03±0.02 g/100 g), lipid (17.90±0.14 g/100 g), protein (15.55±0.36 g/100 g) and moisture (15.10±0.14 g/100 g). It also showed low amounts of ash (2.26±0.23 g/100 g). The seed also presented total oxalate (14.98±0.03 mg/100 g). Levels of tannin (6.98±0.04 mg/100 g) and phytic acid (3.18±0.16 mg/100 g) were also present in low amounts. Conclusion: It seems P. americana seed contains substantial amount of nutrients that could warrant its utilization in animal feed or food.