In this study, we searched the hypolipidemic effects of a dietary fiber in hyperlipidemic and normal rats. Rats were fed with high-fat diet (HFD) or a normal fed diet (NFD) for 12-weeks and then treated with 5, 10 and 20% guar gum in their regime for 28 days. Total cholesterol (TC), triglyceride (TG) and lowdensity lipoprotein cholesterol (LDL-C) were significantly increased in HFD rats, while administration of guar gum significantly lowered them. Serum high-density lipoprotein-cholesterol (HDL-C) was reduced in HFD rats. However, feeding the HFD rats with guar gum markedly elevated HDL-C level. Of the different tested percentage of guar gum in their regimes, 20% guar gum showed the strongest hypolipidemic effect, as well as a high anti atherogenic potential with atherogenic index (A.I.). These results suggested that guar gum may be effective hypolipiedemic agent and may prevent hyperlipidemic atherosclerosis in both hyperlipidemic and normal rats.
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