Comparison of the beneficial effects of guar gum on lipid profile in hyperlipidemic and normal rats

Abstract

In this study, we searched the hypolipidemic effects of a dietary fiber in hyperlipidemic and normal rats. Rats were fed with high-fat diet (HFD) or a normal fed diet (NFD) for 12-weeks and then treated with 5, 10 and 20% guar gum in their regime for 28 days. Total cholesterol (TC), triglyceride (TG) and lowdensity lipoprotein cholesterol (LDL-C) were significantly increased in HFD rats, while administration of guar gum significantly lowered them. Serum high-density lipoprotein-cholesterol (HDL-C) was reduced in HFD rats. However, feeding the HFD rats with guar gum markedly elevated HDL-C level. Of the different tested percentage of guar gum in their regimes, 20% guar gum showed the strongest hypolipidemic effect, as well as a high anti atherogenic potential with atherogenic index (A.I.). These results suggested that guar gum may be effective hypolipiedemic agent and may prevent hyperlipidemic atherosclerosis in both hyperlipidemic and normal rats.

Potentiation of anti-obesity activity of berberine through its encapsulation in guar-acacia gum nanocomplexes in Wistar albino rats

“…The lipid lowering effect of free berberine is also substantiated with an earlier study [46]. The lipid lowering effect of guar gum and gum acacia has also been described in a previous study [47,48]. Hence, Ber/Gu-AGNCs showed a better anti-hyperlipidemic effect than free berberine and Gu-AGNCs.…”

تأثير مساحيق قشر الرمان وصمغ الغار على الفئران المصابة بمرض السکر المستحث بالألوکسان

“…These results agree with that obtained by Daumerie and henquin, (2011) who reported that significant decreases in human serum cholesterol levels following GG ingestion.These decreases are through to be a function of its high soluble fiber content. GG may be effective hypolipiedemic agent and may prevent hyperlipidemic on the arthrosclerosis in both hyperlipidemic and normal rats (Hajzadeh et al, 2012). GG fiber helps in decreasing the levels of cholesterol in experimental animals (www.webMd, 2017).…”

The effects of guar gum supplementation on lipid profile in adults: a GRADE-assessed systematic review, meta-regression and dose–response meta-analysis of randomised placebo-controlled trials

“…Numerous clinical trials have examined the effects of guar gum supplementation on various diseases, such as diabetes, irritable bowel syndrome and dyslipidaemia (16)(17)(18)(19) . Animal studies suggest that guar gum supplementation has hypolipidaemic effects (20)(21)(22) . While numerous human studies have been performed to investigate the effects of guar gum supplementation on lipid profile, results have been contradictory.…”