تأثير مساحيق قشر الرمان وصمغ الغار على الفئران المصابة بمرض السکر المستحث بالألوکسان

Abstract

Pomegranate peel (PP) and guar gum (GG) powder can be submitted many healthy benefits for Human. Therefore, the present study aims to investigate the effect of PP and GG powders and their mixture on diabetic rats induced by alloxan. Forty male Albino rats, weighing 140 ± 10g, were randomly divided into two main groups. The first main group (5 rats) fed on basal diet as a negative control group (healthy rats), while the second main group (35 rats) was diabetic induced by a single intraperitoneal injection of alloxan (150 mg/kg b.w.) then divided into seven sub groups. One of them fed on basal diet as positive control group (diabetic rats) and the other groups fed on basal diet containing 3 and 6% of PP, GG powders and their mixture for five weeks. The results revealed that feeding PP, GG powders and their mixture by diabetic rats improved kidney functions (uric acid and creatinine levels), liver functions (ALT and AST activities), serum glucose and serum lipid profile (cholesterol , triglycerides , LDL and HDL levels). Also, feeding 6% PP has achieved the best results followed by 6% PP + 6% GG when compared to the control group. Therefore, we recommended the using of PP and GG powders as food additives for their nutritional and healthy benefits.