In 2001, the Irish government published a reforming policy intended to modernise and expand the delivery of primary care in Ireland. Fifteen years later, the Irish health system remains beset by problems indicative of a fragmented and underdeveloped primary care system. This case study examines the formation and implementation of the 2001 primary care policy and identifies key risk categories within the policymaking process itself that inhibited the timely achievement of policy objectives. Our methodology includes a directed content analysis of the policy formation and implementation documents and the influencing academic literature, as well as semi-structured interviews with key personnel involved in the process.We identify three broad risk categories -power, resources and capability -within the policymaking process that strongly influenced policy formation and implementation. We additionally show that the disjoint between policy formation and policy implementation was a contested issue among those involved in the policy process and provided space for these risks to critically undermine Ireland's primary care policy.
The emergence of Grid computing technology has opened up an unprecedented opportunity for biologists to share and access data, resources and tools in an integrated environment leading to a greater chance of knowledge discovery. GeneGrid is a Grid computing framework that seamlessly integrates a myriad of heterogeneous resources spanning multiple administrative domains and locations. It provides scientists an integrated environment for the streamlined access of a number of bioinformatics programs and databases through a simple and intuitive interface. It acts as a virtual bioinformatics laboratory by allowing scientists to create, execute and manage workflows that represent bioinformatics experiments. A number of cooperating Grid services interact in an orchestrated manner to provide this functionality. This paper gives insight into the details of the architecture, components and implementation of GeneGrid.
GeneGrid is a collaborative industrial R&D project initiated by the Belfast e-ScienceCentre, under the UK e-Science Programme, with commercial partners involved in the research and development of antibodies and drugs. GeneGrid provides a platform for scientists, especially biologists, to access their collective skills, experiences and results in a secure, reliable and scalable manner through the creation of a 'Virtual Bioinformatics Laboratory'. It enables the seamless integration of a myriad of heterogeneous applications and datasets that span multiple administrative domains and locations across the globe, and present these to the scientist through a simple user friendly interface. This paper presents how the grid services of GeneGrid are involved in the integration of bioinformatics applications as well as in the creation and execution of in silico experiments. A real use case scenario is also presented, involving the identification of novel members belonging to a protein family, for demonstrating the capabilities of GeneGrid.
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