Kupffer-phase Sonazoid-enhanced sonography and hepatobiliary-phase gadoxetic acid-enhanced MRI may be useful in estimating the histologic grade, although Kupffer-phase Sonazoid-enhanced sonography may be more accurate in distinguishing hepatocellular carcinomas, especially moderately and poorly differentiated types.
Purpose: We evaluated the diagnostic e‹cacy of gadoxetic acid-and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for focal nodular hyperplasia (FNH).Materials and Methods: We retrospectively evaluated 11 patients with 11 FNHs. Both gadoxetic acid-and SPIO-enhanced MR imaging were performed. A 3-dimensional (3D) volumetric interpolated breath-hold examination was used with the gadoxetic acid dynamic study. SPIO-enhanced MR imaging included T 2 -and T 2 *-weighted images. We quantitatively and qualitatively compared lesion-speciˆc enhancement of both contrast media.Results: The mean signal-to-noise (S/N) ratio of the FNH lesions diŠered signiˆcantly on pre-and postenhanced imaging of each contrast medium (Pº0.05); mean contrast-tonoise (C/N) ratio did not (PÀ0.05). All observers described all lesions as hyperintense in the arterial phase on gadoxetic acid-enhanced MR imaging and observed the presence of central scar,ˆbrous septa, and rim most clearly in gadoxetic acid-enhanced hepatobiliary phase images.Conclusion: Gadoxetic acid-enhanced MR imaging was more useful than SPIO-enhanced MR imaging in characterizing FNH.
The accuracy of the CNR was highest with b = 0; however, examination at high b-values had advantages in the qualitative evaluation of some small-size lesions.
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