Objective Ferritin is involved in the occurrence of oxidative stress and regulation of adiponectin, both of which can modulate metabolic syndrome (MetS). To investigate the association of ferritin with MetS in Japanese, a cross-sectional study was conducted involving 324 men and 340 women who underwent anti-aging health checks at Tokai University Tokyo Hospital. Results Ferritin levels were significantly higher in the subjects with hyperglycemia and dyslipidemia in both men and women, and in those with abdominal obesity in women. HsCRP levels were significantly higher in the subjects with abdominal obesity in both sexes, and in those with hypertension in men. Serum ferritin increased in proportion to the number of MetS components and was significantly higher in MetS subjects than in non-MetS counterparts in both men and women, although these results were not obtained regarding hsCRP.
Methods
Conclusion
Objective To determine if higher adiponectin levels had any beneficial effects on atherosclerosis-related factors, a longitudinal study was conducted involving 77 subjects who underwent annual anti-aging health checks at Tokai University Tokyo Hospital.
MethodsThe subjects were divided into four groups (Quartile 1, n = 18, adiponectin < 5.9 μg/mL; Quartile 2, n = 19, adiponectin 5.9 to <8.3 μg/mL; Quartile 3, n = 20, adiponectin 8.3 to < 11.4 μg/mL; Quartile 4, n = 20, adiponectin > 11.4 μg/mL). The relationship between basal adiponectin level and the following parameters was evaluated: BMI, systolic and diastolic blood pressure, LDL-C, HDL-C, triglycerides, bilateral mean intima-media thickness (IMT) and lifestyle habits (exercise, smoking, drinking and supplement intake) and medical profile (present illness and past history) at baseline and after three years.
Results
Objective Obesity occurs when energy intake consistently exceeds energy expenditure. Nonexercise activity thermogenesis (NEAT) is an important component of daily energy expenditure. It represents common daily activities, such as fidgeting, walking, and standing. To investigate the relationship of nutrient intake and energy expenditure with obesity, we compared lifestyle habits in obese and non-obese Japanese adults by estimating their nutritional intake and energy expenditure values, focusing on the role of NEAT in obesity. Methods Forty-nine men who underwent anti-aging health checks at Tokai University Tokyo Hospital were enrolled in the study. A food frequency questionnaire (FFQg) was used to estimate nutrient intake and energy expenditure values. Results There was no significant difference in nutrient intake values, and total daily energy expenditure, resting energy expenditure and exercise energy expenditure between the non-obesity and obesity groups. Physical activities excluding exercise were subdivided into the following six categories: sleeping, resting, sedentary activity, light physical activity, moderate physical activity and vigorous physical activity. It was found that the number of hours of light physical activity and moderate physical activity, corresponding to NEAT, was significantly less in the obesity group than in the non-obesity group. Conclusion The present study showed that obesity in Japanese men was associated with decreased NEAT rather than excessive energy intake and/or decreased physical exercise. Approaches to enhance NEAT, for example, changes in posture and movement, could have a substantial impact on the prevention and reduction of obesity.
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