Serum ferritin and high sensitivity C-reactive protein are associated with metabolic syndrome in Japanese men and women

Abstract

Objective Ferritin is involved in the occurrence of oxidative stress and regulation of adiponectin, both of which can modulate metabolic syndrome (MetS). To investigate the association of ferritin with MetS in Japanese, a cross-sectional study was conducted involving 324 men and 340 women who underwent anti-aging health checks at Tokai University Tokyo Hospital. Results Ferritin levels were significantly higher in the subjects with hyperglycemia and dyslipidemia in both men and women, and in those with abdominal obesity in women. HsCRP levels were significantly higher in the subjects with abdominal obesity in both sexes, and in those with hypertension in men. Serum ferritin increased in proportion to the number of MetS components and was significantly higher in MetS subjects than in non-MetS counterparts in both men and women, although these results were not obtained regarding hsCRP. Methods Conclusion

Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders

“…Swaminathan et al [27] have reported that iron causes insulin resistance, pancreatic β cell dysfunction, and hepatic dysfunction. Additionally, Yamada et al [28] have reported that serum ferritin level increases as more diagnostic criteria of metabolic syndrome are fulfilled and that ferritin is a potential biomarker in metabolic syndrome. From these findings, the laboratory data related to metabolic syndrome, such as UA, insulin, and ferritin, may also be useful in evaluating the LEL patients and understanding the underlying causes in the idiopathic cases.…”

Anti-aging health check-up system—Current overview of anti-aging medicine in Japan and experiences from anti-aging health check-ups at Tokai University Tokyo Hospital—

“…In relation to oxidative stress, we reported that ferritin is an important oxidative stress marker. Ferritin is involved in the occurrence of oxidative stress and the regulation of adiponectin, and we demonstrated that ferritin as a potent biomarker for metabolic syndrome 15) . The serum total anti-oxidant status was significantly correlated with uric acid, vitamin A, folate, and valine.…”

“…In addition, to investigate the relationship of nutrient intake and energy expenditure with obesity, we compared lifestyle habits in obese and non-obese Japanese men by estimating their nutritional intake and energy expenditure values 14) . It was shown that obesity was associated with decreased nonexercise activity thermogenesis (NEAT), and that approaches to enhance NEAT, for example, changes in posture and movement, could have a substantial impact on the prevention and reduction of obesity 15) .…”