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This paper proposes a new generalized two dimensional learning approach for particle swarm based feature selection. The core idea of the proposed approach is to include the information about the subset cardinality into the learning framework by extending the dimension of the velocity. The 2D-learning framework retains all the key features of the original PSO, despite the extra learning dimension. Most of the popular variants of PSO can easily be adapted into this 2D learning framework for feature selection problems. The efficacy of the proposed learning approach has been evaluated considering several benchmark data and two induction algorithms: Naive-Bayes and k-Nearest Neighbor. The results of the comparative investigation including the time-complexity analysis with GA, ACO and five other PSO variants illustrate that the proposed 2D learning approach gives feature subset with relatively smaller cardinality and better classification performance with shorter run times.

This is an important contribution toward closed-loop validation of cardiac devices using real-time heart models.

Organ level simulation of bioelectric behavior in the body benefits from flexible and efficient models of cellular membrane potential. These computational organ and cell models can be used to study the impact of pharmaceutical drugs, test hypotheses, assess risk and for closed-loop validation of medical devices. To move closer to the real-time requirements of this modeling a new flexible Fourier based general membrane potential model, called as a Resonant model, is developed that is computationally inexpensive. The new model accurately reproduces non-linear potential morphologies for a variety of cell types. Specifically, the method is used to model human and rabbit sinoatrial node, human ventricular myocyte and squid giant axon electrophysiology. The Resonant models are validated with experimental data and with other published models. Dynamic changes in biological conditions are modeled with changing model coefficients and this approach enables ionic channel alterations to be captured. The Resonant model is used to simulate entrainment between competing sinoatrial node cells. These models can be easily implemented in low-cost digital hardware and an alternative, resource-efficient implementations of sine and cosine functions are presented and it is shown that a Fourier term is produced with two additions and a binary shift.

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