Abstract-In this paper, we construe key factors in design and evaluation of image processing algorithms on the massive parallel graphics processing units (GPUs) using the compute unified device architecture (CUDA) programming model. A set of metrics, customized for image processing, is proposed to quantitatively evaluate algorithm characteristics. In addition, we show that a range of image processing algorithms map readily to CUDA using multiview stereo matching, linear feature extraction, JPEG2000 image encoding, and nonphotorealistic rendering (NPR) as our example applications. The algorithms are carefully selected from major domains of image processing, so they inherently contain a variety of subalgorithms with diverse characteristics when implemented on the GPU. Performance is evaluated in terms of execution time and is compared to the fastest host-only version implemented using OpenMP. It is shown that the observed speedup varies extensively depending on the characteristics of each algorithm. Intensive analysis is conducted to show the appropriateness of the proposed metrics in predicting the effectiveness of an application for parallel implementation.

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Evidence from animal studies categorizes sporadic Alzheimer's disease (sAD) as a metabolic syndrome with accompanying cognitive deficits. Given that glial cells act as "silent partners" to neurons by providing trophic support and defense, the present study investigated the role of glia in sAD pathology. A streptozotocin (STZ)-induced glial-neuronal co-culture model of sAD was used to study the metabolic status of the two cell types. Real time RT-PCR and Western blotting results indicated that amyloid precursor protein (APP) and β-secretase (BACE1) were highly expressed in co-cultured neurons than in monocultures. Increased amyloidogenesis was accompanied by decreased expression of mediators in insulin signaling pathway that included insulin receptor (IR), insulin receptor substrate 2 (IRS2), insulin-like growth factor 2 (IGF2), insulin-like growth factor 1 receptor (IGF1R), total-glycogen synthase kinase 3β (t-GSK3β), and phosphorylated-GSK3β (p-GSK3β), suggesting that neuronal cells are more prone to metabolic variability when cultured in the presence of glial cells. Findings from the sAD model induced by intracerebroventricular (ICV) injection of STZ revealed that increased amyloid beta (Aβ) load in the hippocampus was potentially responsible for the hyperphosphorylation of tau at ser. Furthermore, impaired cognitive functions and decreased dendritic spine density and axonal thinning in CA1 region of hippocampus were associated with decreased IR and p-GSK3β/t-GSK3β expression. Taken together, the present study provides evidence that glia mediated response and insulin signaling defects drive pathological changes in sAD and represent potential targets for delaying sAD progression.

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Novel N-methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain-breaking and glutathione peroxidase (GPx)-like activities. These could also inhibit the lipid peroxidation much...