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The step-by-step redox process of bis-[2-phenyl-1,2-benzisoselenazol-3(2H)-one-7-yl]diazene i.e. azo-bis-ebselen in the presence of PhSH and H2O2 was reported by using 77Se{1H} NMR spectroscopy. The synthesis of N-thiophenyl ebselenamines as well as...

Novel N-methylated ebselenamine antioxidants were prepared from their corresponding diselenides with iodomethane. All ebselenamines showed excellent chain-breaking and glutathione peroxidase (GPx)-like activities. These could also inhibit the lipid peroxidation much...

Selenazolonamines 10 a-d with free amine (-NH 2 ) group, a new series of preventive and radical-trapping antioxidants were synthesized from their corresponding diselenides. The radical-trapping antioxidant capacity of compounds 10 a-d was determined in a chlorobenzene/ water membrane-like model system in which azo-initiated peroxidation of linoleic acid was carried out in the lipid phase. The regeneration occurred in the aqueous ascorbic acid as co-antioxidant, which could regenerate the antioxidants and enhance their inhibition times. The best antioxidant 10 d substituted with para-NMe 2 a strong electron-donating group quenched the peroxyl radicals more efficiently than α-tocopherol almost 5.5-fold longer inhibition time. The novel selenazolonamines 10 a-d and their derivatives exhibited good preventive i. e. glutathione peroxidaselike activity in the coupled reductase assay. Based on 77 Se NMR spectroscopy, a catalytic cycle for 10 d, involving diselenide, selenosulfide, and selenol as intermediates was proposed. The mechanism for quenching of peroxyl radicals for 10 d was also considered to be involved via protoncoupled electron transfer reaction.

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The choice to use teeth for age determination is well accepted due to their longevity ability of being resilient to change. The total of 228 extracted teeth collected from the patients visited to the Department of Oral and Maxillofacial Surgery, NIMS Dental College, Jaipur, the teeth were without dental fillings and without and/or cavity selected. The known age was from 21 to 70 years with the average age of 43.46 years. For age estimation the method according to Gustafson was used. Every tooth was subject to longitudinal section of the midpulpal area. The following dental parameters were studied in each case: attrition, periodontal bone loss, root translucency, secondary dentin deposition, cementum apposition and root resorption. Total scores of different parameters plotted against the chronological age and regression formula was obtained. Using this formula ages were estimated, Gustafson formula was also applied in the same scores and ages estimated. The results of the chronological and estimated age by both formulae have been statistically compared using Pearson's correlation and regression analysis. The results showed strong correlation (0.92; p<0.001) between chronological and estimated age by using both formulae. We found the mean error of ±5.47 by using newly derived and formula and ±6.35 by Gustafson's formula. As a result of our study it was found that newly derived formula provides better results in comparison with Gustafson's formula in Indian population. A positive correlation between age and total scores of physiological changes also revealed.

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Bis(3-amino-1-hydroxybenzyl)diselenide containing two ortho groups was synthesized from 7-nitro-3H-2,1-benzoxaselenole and in situ generated sodium benzene tellurolate (PhTeNa). One-pot synthesis of 1,3-benzoselenazoles was achieved from bis(3-amino-1-hydroxybenzyl)diselenide and aryl aldehydes using acetic acid as a catalyst. The X-ray crystal structure of chloro-substituted benzoselenazole revealed a planar structure with T-shaped geometry around the Se atom. Both natural bond orbital and atoms in molecules calculations confirmed the presence of secondary Se···H interactions in bis(3-amino-1-hydroxybenzyl)diselenide and Se···O interactions in benzoselenazoles, respectively. The glutathione peroxidase (GPx)-like antioxidant activities of all compounds were evaluated using a thiophenol assay. Bis(3-amino-1-hydroxybenzyl)diselenide and benzoselenazoles showed better GPx-like activity compared to that of the diphenyl diselenide and ebselen, used as references, respectively. Based on 77Se{1H} NMR spectroscopy, a catalytic cycle for bis(3-amino-1-hydroxybenzyl)diselenide using thiophenol and hydrogen peroxide was proposed involving selenol, selenosulfide, and selenenic acid as intermediates. The potency of all GPx mimics was confirmed by their in vitro antibacterial properties against the biofilm formation of Bacillus subtilis and Pseudomonas aeruginosa. Additionally, molecular docking studies were used to evaluate the in silico interactions between the active sites of the TsaA and LasR-based proteins found in Bacillus subtilis and Pseudomonas aeruginosa.